MODAFINIL AS A TREATMENT FOR METHAMPHETAMINE DEPENDENCE: INITIAL SAFETY, SUBJ

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 1.收集关于在莫达非尼甲基苯丙胺依赖者治疗期间甲基苯丙胺的心血管、主观和强化效应的初步数据。根据先前评估莫达非尼治疗可卡因依赖的安全性和有效性的试验结果[Dackis，2003#3188；Dackis，2005#3869]，我们预计不会有不良交互作用(如增强甲基苯丙胺的心血管效应)，并预测莫达非尼将减少甲基苯丙胺的主观和强化效应。 2.确定莫达非尼(在没有和存在甲基苯丙胺的情况下)是否改善认知功能，特别是与抑制控制有关的功能。慢性虐待与不良反应、抑制和其他与执行功能有关的神经认知缺陷有关(例如，Kalechstein，2003a)。先前的报告表明，莫达非尼改善了其他临床人群中类似的认知缺陷(例如，Turner 2004a)。参与者将在整个试验过程中接受行为测试，以监测该药物对抑制控制认知措施的急性影响，以及短暂长期服药期间的影响。我们预计，莫达非尼的应用将与抑制控制测试中性能的改善有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. Collect initial data on the cardiovascular, subjective, and reinforcing effects of methamphetamine during treatment with modafinil methamphetamine-dependent subjects. Based on results of prior trials that assessed the safety and efficacy of modafinil for cocaine dependence [Dackis, 2003 #3188;Dackis, 2005 #3869], we anticipate no adverse interaction (such as an enhancement of the cardiovascular effects of methamphetamine), and predict that modafinil will reduce the subjective and reinforcing effects of methamphetamine. 2. Determine whether modafinil (both in the absence and presence of methamphetamine) improves cognitive functioning, especially related to inhibitory control. Chronic abuse is associated with poor response inhibition and other neurocognitive deficits related to executive function (e.g., Kalechstein 2003a). Prior reports suggest that modafinil improves similar cognitive deficits in other clinical populations (e.g., Turner 2004a). Participants will undergo behavioral tests throughout the trial to monitor both acute effects of the drug on cognitive measures of inhibitory control, as well as effects during brief chronic dosing. We anticipate that modafinil administration will be associated with improved performance on tests of inhibitory control.