MODAFINIL AS A TREATMENT FOR METHAMPHETAMINE DEPENDENCE: INITIAL SAFETY, SUBJ

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 具体目标： 1. 收集莫达非尼甲基苯丙胺依赖受试者治疗期间甲基苯丙胺对心血管、主观和强化作用的初始数据。 根据先前评估莫达非尼治疗可卡因依赖的安全性和有效性的试验结果[Dackis，2003 #3188;Dackis，2005 #3869]，我们预计没有不良相互作用（如增强甲基苯丙胺的心血管作用），并预测莫达非尼将减少甲基苯丙胺的主观和强化作用。 2. 确定莫达非尼（无论是否存在甲基苯丙胺）是否改善认知功能，特别是与抑制控制相关的认知功能。 慢性滥用与不良反应抑制和与执行功能相关的其他神经认知缺陷（例如，Kalechstein 2003 a）。 先前的报道表明莫达非尼改善了其他临床人群中类似的认知缺陷（例如，Turner 2004 a）。 参与者将在整个试验期间接受行为测试，以监测药物对抑制控制的认知测量的急性影响以及短暂慢性给药期间的影响。 我们预计，莫达非尼管理将与抑制控制测试的性能改善。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. Collect initial data on the cardiovascular, subjective, and reinforcing effects of methamphetamine during treatment with modafinil methamphetamine-dependent subjects. Based on results of prior trials that assessed the safety and efficacy of modafinil for cocaine dependence [Dackis, 2003 #3188;Dackis, 2005 #3869], we anticipate no adverse interaction (such as an enhancement of the cardiovascular effects of methamphetamine), and predict that modafinil will reduce the subjective and reinforcing effects of methamphetamine. 2. Determine whether modafinil (both in the absence and presence of methamphetamine) improves cognitive functioning, especially related to inhibitory control. Chronic abuse is associated with poor response inhibition and other neurocognitive deficits related to executive function (e.g., Kalechstein 2003a). Prior reports suggest that modafinil improves similar cognitive deficits in other clinical populations (e.g., Turner 2004a). Participants will undergo behavioral tests throughout the trial to monitor both acute effects of the drug on cognitive measures of inhibitory control, as well as effects during brief chronic dosing. We anticipate that modafinil administration will be associated with improved performance on tests of inhibitory control.