Effects of Oral Contraceptives on Emotion Regulation

口服避孕药对情绪调节的影响

基本信息

项目摘要

 DESCRIPTION (provided by applicant): Although ample evidence has documented sex differences in the course of drug addiction, neuroendocrine contributions to these sex differences have not been fully explored. Oral contraceptive pills are used by the majority of women in the US for at least one period of their reproductive years, and dramatically decrease sex hormone levels. However, any potential relationship between oral contraceptives and drug abuse/dependence that may relate to or explain previously observed sex differences has never been formally investigated to our knowledge. We hypothesize that the change in hormones caused by oral contraceptive use can decrease performance on an emotion regulation task that activates regions of the brain previously shown be less active in oral contraceptive users. Deficits in emotion regulation have been linked to substance abuse problems. Therefore, we propose to investigate whether oral contraceptives decrease emotion regulation as a first step toward determining whether they can influence efforts toward drug abstinence.
 描述(由申请人提供):尽管有充分的证据证明了药物成瘾过程中的性别差异,但尚未充分探讨神经内分泌对这些性别差异的贡献。口服避孕药被大多数美国妇女在其生育年龄的至少一个时期使用,并显着降低性激素水平。然而,据我们所知,口服避孕药和药物滥用/依赖之间可能与或解释先前观察到的性别差异的任何潜在关系从未被正式调查过。我们假设,口服避孕药使用引起的激素变化可能会降低情绪调节任务的表现,该任务激活了口服避孕药使用者先前表现不太活跃的大脑区域。情绪调节的缺陷与药物滥用问题有关。因此,我们建议调查口服避孕药是否会降低情绪调节,作为确定它们是否会影响戒毒努力的第一步。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Effects of oral contraceptive pills on mood and magnetic resonance imaging measures of prefrontal cortical thickness.
  • DOI:
    10.1038/s41380-020-00990-2
  • 发表时间:
    2021-03
  • 期刊:
  • 影响因子:
    11
  • 作者:
    Petersen N;Kearley NW;Ghahremani DG;Pochon JB;Fry ME;Rapkin AJ;London ED
  • 通讯作者:
    London ED
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Edythe Danick London其他文献

Edythe Danick London的其他文献

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{{ truncateString('Edythe Danick London', 18)}}的其他基金

Neural Substrates of Cigarette Craving, Withdrawal, and Relief: Male-Female Differences
香烟渴望、戒断和缓解的神经基础:男女差异
  • 批准号:
    10475684
  • 财政年份:
    2020
  • 资助金额:
    $ 19.25万
  • 项目类别:
Neural Substrates of Cigarette Craving, Withdrawal, and Relief: Male-Female Differences
香烟渴望、戒断和缓解的神经基础:男女差异
  • 批准号:
    9927803
  • 财政年份:
    2020
  • 资助金额:
    $ 19.25万
  • 项目类别:
Neural Substrates of Cigarette Craving, Withdrawal, and Relief: Male-Female Differences
香烟渴望、戒断和缓解的神经基础:男女差异
  • 批准号:
    10259663
  • 财政年份:
    2020
  • 资助金额:
    $ 19.25万
  • 项目类别:
Exercise in Methamphetamine Use Disorder: Dopamine Receptor Upregulation and Neural Function
甲基苯丙胺使用障碍的运动:多巴胺受体上调和神经功能
  • 批准号:
    10398834
  • 财政年份:
    2018
  • 资助金额:
    $ 19.25万
  • 项目类别:
Exercise in Methamphetamine Use Disorder: Dopamine Receptor Upregulation and Neural Function
甲基苯丙胺使用障碍的运动:多巴胺受体上调和神经功能
  • 批准号:
    10153743
  • 财政年份:
    2018
  • 资助金额:
    $ 19.25万
  • 项目类别:
Exercise in Methamphetamine Use Disorder: Dopamine Receptor Upregulation and Neural Function
甲基苯丙胺使用障碍的运动:多巴胺受体上调和神经功能
  • 批准号:
    9915871
  • 财政年份:
    2018
  • 资助金额:
    $ 19.25万
  • 项目类别:
Neural substrates of cigarette craving, withdrawal, and relief: male-female differences
香烟渴望、戒断和缓解的神经基质:男女差异
  • 批准号:
    9988005
  • 财政年份:
    2017
  • 资助金额:
    $ 19.25万
  • 项目类别:
Neural Substrates of Cigarette Craving, Withdrawal, and Relief: Male-Female Differences
香烟渴望、戒断和缓解的神经基础:男女差异
  • 批准号:
    10534070
  • 财政年份:
    2017
  • 资助金额:
    $ 19.25万
  • 项目类别:
Neural substrates of cigarette craving, withdrawal, and relief: male-female differences
香烟渴望、戒断和缓解的神经基质:男女差异
  • 批准号:
    9763529
  • 财政年份:
    2017
  • 资助金额:
    $ 19.25万
  • 项目类别:
Behavioral and Neural Response to Reduced Nicotine Cigarettes in Young Smokers
年轻吸烟者对减少尼古丁香烟的行为和神经反应
  • 批准号:
    8606043
  • 财政年份:
    2013
  • 资助金额:
    $ 19.25万
  • 项目类别:

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