ROLES OF 20-HYDROXYEICOSATETRAENOIC ACIDS (20-HETE) IN EXCECISE PRESSOR REFLEX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在运动过程中，交感神经系统（SNS）被激活，并有助于血压，心率和外周血管收缩的增加。SNS激活的两个基本理论已经发展：中央命令和由机械敏感（机械感受器）和化学敏感（化学感受器）传入触发的运动升压反射。在这项研究中，我们将重点关注代谢受体（特别是肾上腺素），看看是否通过酮咯酸阻断肾上腺素的作用，它会减少对握力运动的反射反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During exercise, the sympathetic nervous system (SNS) is activated and contributes to an increase in blood pressure, heart rate and peripheral vasoconstriction. Two basic theories of SNS activation have evolved: central command and the exercise pressor reflex triggered by mechanically sensitive (mechanoreceptors) and chemically sensitive (chemoreceptors) afferents. In this study, we will focus on metaboreceptors (specifically prostaglandins) and see if by blocking the action of prostaglandins with Ketorolac, it will decrease the reflex response to handgrip exercise.