ROLES OF 20-HYDROXYEICOSATETRAENOIC ACIDS (20-HETE) IN EXCECISE PRESSOR REFLEX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在运动中，交感神经系统(SNS)被激活，有助于增加血压、心率和外周血管收缩。SNS激活的两个基本理论已经演变：中枢命令和由机械敏感(机械感受器)和化学敏感(化学感受器)传入触发的运动升压反射。在这项研究中，我们将重点放在代谢物受体(特别是前列腺素)上，看看通过用酮洛酸阻断前列腺素的作用，它是否会减少握手运动的反射反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During exercise, the sympathetic nervous system (SNS) is activated and contributes to an increase in blood pressure, heart rate and peripheral vasoconstriction. Two basic theories of SNS activation have evolved: central command and the exercise pressor reflex triggered by mechanically sensitive (mechanoreceptors) and chemically sensitive (chemoreceptors) afferents. In this study, we will focus on metaboreceptors (specifically prostaglandins) and see if by blocking the action of prostaglandins with Ketorolac, it will decrease the reflex response to handgrip exercise.