ROLE OF ADENOSINE AND P2X RECEPTORS IN THE EXERCISE PRESSOR REFLEX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目的目标是检查人体内产生的一种化学物质(腺苷)和体内细胞上发现的一种受体(P2X受体)是否参与了导致受试者在运动过程中血压和心率上升的反射。如果腺苷(用一种名为氨茶碱的药物)的作用被阻断，或者如果受体被维生素B6阻断，运动反应减弱，这将表明腺苷或P2X受体参与其中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal for this project is to examine if a chemical produced in the body (adenosine) and a receptor found on the cells in the body (P2X receptors) are involved in the reflex that causes a rise in blood pressure and heart rate during exercise in human subjects. If the action of the adenosine (with a drug called aminophylline) is blocked or if the receptor is blocked with Vitamin B6, and the exercise response is reduced, this will show that adenosine or the P2X receptor is involved.