ROLE OF ADENOSINE AND P2X RECEPTORS IN THE EXERCISE PRESSOR REFLEX

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的目的是研究人体内产生的化学物质（腺苷）和体内细胞上发现的受体（P2 X受体）是否参与了人体受试者在运动期间导致血压和心率上升的反射。 如果腺苷的作用（用一种叫做氨茶碱的药物）被阻断，或者如果受体被维生素B6阻断，运动反应降低，这将表明腺苷或P2 X受体参与其中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal for this project is to examine if a chemical produced in the body (adenosine) and a receptor found on the cells in the body (P2X receptors) are involved in the reflex that causes a rise in blood pressure and heart rate during exercise in human subjects. If the action of the adenosine (with a drug called aminophylline) is blocked or if the receptor is blocked with Vitamin B6, and the exercise response is reduced, this will show that adenosine or the P2X receptor is involved.