NEUROVASCULAR CONTROL IN DIASTOLIC HEART FAILURE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是评估交感神经系统在舒张性心力衰竭患者神经血管控制中的作用。 在本方案中，研究者计划研究由于舒张性心功能不全而导致慢性心力衰竭的患者在休息、运动（握力运动）和直立性应激（头高位倾斜）期间的肌肉交感神经活动和血浆去甲肾上腺素水平。 他们还计划研究运动对这些患者肾血流量的影响

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main objective of this study is to evaluate the role of sympathetic nervous system in neurovascular control in patients with diastolic heart failure. In this protocol, the investigators plan to study muscle sympathetic nerve activity and plasma norepinephrine levels in patients with chronic heart failure due to diastolic heart dysfunction during rest, exercise (handgrip exercise) and orthostatic stress (head up tilt). They also plan to study the effects of exercise on renal blood flow in these patients