GEN-RED
GEN-RED
批准号:
7951430
负责人:
WILLIAM Bradford LAWSON
金额:
$2.13万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-03-01 至 2010-02-28
关键词:
15q17pAffectAfrican AmericanBlindedBlood specimenCell Culture TechniquesCell LineChromosomesClinicalClinical DataClinical ResearchCollectionComputer Retrieval of Information on Scientific Projects DatabaseDepositionDiagnosticEuropeanFamilyFundingGenome ScanGrantInstitutionMajor Depressive DisorderMapsModelingNational Institute of Mental HealthParentsRecurrenceRelative (related person)ResearchResearch PersonnelResourcesSamplingSiblingsSiteSourceSusceptibility GeneUnited States National Institutes of HealthUniversitiesbasedepressionearly onsetgenome-widemalemeetingspositional cloningprobandrepositorysex
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
This is a second revision of a collaborative R01 four-year competing continuation proposal to create a large repository-based sample of cases with recurrent, early-onset major depressive disorder (MDD-RE), and to use positional cloning to identify depression susceptibility genes in regions of significant linkage in our genome scan. The completed four-year project collected 680 families containing 927 affected sibling pairs (ASPs) (MDD-RE diagnostic model) and additional affected relatives (GenRED I). Blinded clinical data and blood specimens for cell culture were deposited in the NIMH repository and are being made public. Linkage fine-mapping has demonstrated genome-wide significant linkage on chromosome 15q; in the 10 cM genome scan, suggestive sex-specific linkage was observed in three regions (6p-q, 8p, 17p), with the result on chromosome 17p approaching genome-wide significance. Six collaborating sites now propose to: (1) Collect (during Years 1-3) an additional 1,350 European-ancestry (EUR) MDD-RE probands (GenRED II) meeting identical criteria (including evidence of having an affected sibling) to create a total repository sample of 2,000 EUR MDD-RE cases, plus cell lines/DMA from available parents, unaffected sibs and male-male ASPs. (2) Initiate a repository-based collection of African-American (AA) MDD-RE probands meeting the same clinical criteria.
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会议论文
GEN BD
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批准号:7607818
-
项目类别:
-
资助金额:$15.46万
-
财政年份:2007
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
GEN-RED
-
批准号:7607834
-
项目类别:
-
资助金额:$9.61万
-
财政年份:2007
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
ETHICS
-
批准号:7378692
-
项目类别:
-
资助金额:$0.13万
-
财政年份:2006
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
GEN-RED
-
批准号:7378693
-
项目类别:
-
资助金额:$2.12万
-
财政年份:2006
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
CLINICAL EVALUATION OF SURFACTANT GENE MUTATIONS
-
批准号:7605578
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项目类别:
-
资助金额:$0.65万
-
财政年份:2006
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
GEN BD
-
批准号:7378677
-
项目类别:
-
资助金额:$13.74万
-
财政年份:2006
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
CLINICAL EVALUATION OF SURFACTANT GENE MUTATIONS
-
批准号:7731403
-
项目类别:
-
资助金额:$0.03万
-
财政年份:2006
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Genetics of Early-Onset Depression
-
批准号:6988223
-
项目类别:
-
资助金额:$26.64万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Genetics of Early-Onset Depression
-
批准号:7124662
-
项目类别:
-
资助金额:$26.01万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Ethnicity and the Diagnosis of Affective Illness
-
批准号:7094243
-
项目类别:
-
资助金额:$25.08万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
GEN BD
-
批准号:7203712
-
项目类别:
-
资助金额:$5.27万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Genetics of Early-Onset Depression
-
批准号:7476566
-
项目类别:
-
资助金额:$25.26万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Ethnicity and the Diagnosis of Affective Illness
-
批准号:7257186
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项目类别:
-
资助金额:$24.35万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
CLINICAL EVALUATION OF SURFACTANT GENE MUTATIONS
-
批准号:7375656
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项目类别:
-
资助金额:$0.21万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
A RANDOMIZED, PLACEBO CONTROLLED,DOUBLE BLIND,PROSPECTIVE STUDY OF CO-ENZYME Q10
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批准号:7375352
-
项目类别:
-
资助金额:$0.04万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
PRAM-C
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批准号:7203701
-
项目类别:
-
资助金额:$1.41万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Ethnicity and the Diagnosis of Affective Illness
-
批准号:7475824
-
项目类别:
-
资助金额:$24.35万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
LIPITOR/EZETIMIBE EFFICACY IN AN ALTERNATE DAY REGIMEN (LEADR)
-
批准号:7375363
-
项目类别:
-
资助金额:$0.04万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Ethnicity and the Diagnosis of Affective Illness
-
批准号:6922592
-
项目类别:
-
资助金额:$25.68万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
Genetics of Early-Onset Depression
-
批准号:7258926
-
项目类别:
-
资助金额:$25.26万
-
财政年份:2005
-
负责人:WILLIAM Bradford LAWSON
-
依托单位:
国内基金
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