GEN-RED

GEN-RED

• 批准号: 7951430
• 负责人: WILLIAM Bradford LAWSON
• 金额: $ 2.13万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951430
• 关键词: 15q; 17p; Affect; African American; Blinded; Blood specimen; Cell Culture Techniques; Cell Line; Chromosomes; Clinical; Clinical Data; Clinical Research; Collection; Computer Retrieval of Information on Scientific Projects Database; Deposition; Diagnostic; European; Family; Funding; Genome Scan; Grant; Institution; Major Depressive Disorder; Maps; Modeling; National Institute of Mental Health; Parents; Recurrence; Relative (related person); Research; Research Personnel; Resources; Sampling; Siblings; Site; Source; Susceptibility Gene; United States National Institutes of Health; Universities; base; depression; early onset; genome-wide; male; meetings; positional cloning; proband; repository; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a second revision of a collaborative R01 four-year competing continuation proposal to create a large repository-based sample of cases with recurrent, early-onset major depressive disorder (MDD-RE), and to use positional cloning to identify depression susceptibility genes in regions of significant linkage in our genome scan. The completed four-year project collected 680 families containing 927 affected sibling pairs (ASPs) (MDD-RE diagnostic model) and additional affected relatives (GenRED I). Blinded clinical data and blood specimens for cell culture were deposited in the NIMH repository and are being made public. Linkage fine-mapping has demonstrated genome-wide significant linkage on chromosome 15q; in the 10 cM genome scan, suggestive sex-specific linkage was observed in three regions (6p-q, 8p, 17p), with the result on chromosome 17p approaching genome-wide significance. Six collaborating sites now propose to: (1) Collect (during Years 1-3) an additional 1,350 European-ancestry (EUR) MDD-RE probands (GenRED II) meeting identical criteria (including evidence of having an affected sibling) to create a total repository sample of 2,000 EUR MDD-RE cases, plus cell lines/DMA from available parents, unaffected sibs and male-male ASPs. (2) Initiate a repository-based collection of African-American (AA) MDD-RE probands meeting the same clinical criteria.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这是R 01合作四年竞争性延续提案的第二次修订，该提案旨在创建一个基于大型储存库的复发性早发性重度抑郁症MDD-RE病例样本，并使用位置克隆来识别我们基因组扫描中显著连锁区域中的抑郁症易感基因。完成的四年项目收集了680个家庭，包括927个受影响的兄弟姐妹对ASPs MDD-RE诊断模型和其他受影响的亲属GenRED I。用于细胞培养的盲态临床数据和血液标本存放在NIMH储存库中，并正在公开。连锁精细定位结果表明，在15号染色体q上存在全基因组显著连锁;在10 cM基因组扫描中，在6p-q、8 p、17 p三个区域观察到了暗示性的性别特异连锁，其中17 p区域的结果接近全基因组显著连锁。6个合作研究中心现在建议：1在第1-3年期间收集另外1，350名符合相同标准的欧洲血统EUR MDD-RE先证者GenRED II，包括有受影响同胞的证据，以创建2，000 EUR MDD-RE病例的总储存库样本，加上来自可用父母、未受影响同胞和男性-男性ASP的细胞系/DMA。(2启动一个基于储存库的符合相同临床标准的非裔美国人AA MDD-RE先证者的收集。