URINE SCREEN OF TYPE 2 DM WITH AND WITHOUT NEPHROPATHY FOR INFLAMMATORY MARKERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 大约6%的美国人口，或者说近1700万人被诊断为糖尿病。与普通人群相比，糖尿病患者的心血管和肾脏疾病的发病率更高。有证据表明，炎症可能是这些情况发生的主要因素。这项研究的目的是比较糖尿病患者的炎症标志物水平，这些患者的尿蛋白高于正常水平，尿蛋白是糖尿病肾病(糖尿病肾病)的标志。符合条件的患者为18-70岁的II型糖尿病患者，并有早期肾脏疾病的迹象。这项先导性研究的结果将被用于设计更大规模的试验，以检查糖尿病肾病和较高心血管疾病之间的关系。这些结果可能会为识别心血管事件或肾脏疾病进展的高风险患者提供潜在的工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. About six percent of the U.S. population or almost 17 million individuals are diagnosed with diabetes mellitus. Diabetic individuals have a higher rate of cardiovascular and kidney disease compared to the general population. Evidence has shown that inflammation may be a major factor for development of these conditions. The goal of this study is to compare levels of inflammatory markers in diabetics who have and who do not have higher than normal urine protein, a sign of diabetic kidney disease (diabetic nephropathy). Eligible patients are 18-70 years old with type II diabetes and signs of early kidney disease. The results of this pilot study will be used to design larger trials to examine the relationship between diabetic nephropathy and higher cardiovascular disease. These results could potentially provide tools to identify patients at higher risk for cardiovascular events or progression of kidney disease.