SUBCLINICAL CVD IN AFRICAN AMERICAN TYPE 2 DIABETICS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 心血管疾病(CVD)是糖尿病患者死亡和残疾的主要原因。与欧洲裔美国人相比，非洲裔美国人患2型糖尿病和糖尿病并发症的风险特别高。这项研究将测量遗传因素(基因)在多大程度上促进患有糖尿病的非裔美国人患心血管疾病的风险，并评估亚临床心血管疾病的种族差异的原因。非裔美国人患心血管疾病的风险被认为是由基因和生活方式共同调节的，但可归因于基因和他们的身份的风险的大小尚不清楚。这项研究将测量这种风险的大小，并在患有2型糖尿病的非裔美国兄弟姐妹中寻找导致心血管疾病的基因。亚临床心血管疾病的评估将使用复杂的、非侵入性的方法：超声测量颈动脉壁厚度和使用计算机断层扫描(CT扫描)测量冠状动脉中的钙。附加的辅助指标是肥胖和骨密度。这项研究将创建一个独特的非裔美国人糖尿病家庭的集合，为心血管疾病的研究提供相关信息。识别心血管疾病风险基因将为开发新的治疗方法提供机会，以预防或推迟患有糖尿病的非裔美国人的心血管疾病的发病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease (CVD) is the leading cause of death and disability in individuals with diabetes. African Americans are at particularly high risk for developing type 2 diabetes and diabetic complications, relative to European Americans. This study will measure the extent to which inherited factors (genes) contribute to the risk of developing CVD in African Americans with diabetes and evaluate the causes of ethnic differences in subclinical CVD. The risk for developing CVD in African Americans is thought to be mediated by both genes and lifestyle, but the size of the risk attributable to genes and their identity are unknown. This study will measure the size of that risk and search for genes that contribute to CVD in pairs of African American siblings with type 2 diabetes. Subclinical CVD will be evaluated using sophisticated, noninvasive, methods: ultrasound measurement of the thickness of carotid artery walls and measurement of calcium in coronary arteries using computed tomography (CT scans). Additional ancillary measures are obesity and bone density. This study will create a unique collection of African American diabetic families with associated information for the study of CVD. The identification of CVD risk genes would provide opportunities to develop new treatments to prevent or delay the onset of CVD in African American individuals with diabetes.