PROGESTERONE SUPPRESSION OF PUBERTAL NOCTURNAL LH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在青春期，黄体生成素(LH)的脉冲频率和幅度在夜间增加，但在白天又变慢。数据显示，在青春期，雌二醇(E2)和孕酮(P)也会在一夜之间升高。我们假设早晨P和E_2的增加有助于抑制第二天的黄体生成素的搏动。早些时候的一项研究表明，在青春期，服用雌二醇会抑制夜间黄体生成素搏动性的增加。然而，对成年人的研究表明，P是促黄体生成素脉冲频率减慢的主要影响因素。目前尚不清楚P是否能抑制青春期夜间黄体生成素搏动性的增加。为了进一步评估这一点，我们将研究青春期早期到中期的正常女孩。志愿者将在GCRC进行频繁的抽样研究。口服P或安慰剂将在1600小时和2000小时给予(根据随机)。1900-0900小时的频繁采血将评估服用P或安慰剂后黄体生成素脉搏频率的夜间变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During puberty, luteinizing hormone (LH) pulse frequency and amplitude increase overnight, but slow again during the day. Data suggest that estradiol (E2) and progesterone (P) also increase overnight during puberty. We have hypothesized that morning increases in P and E2 help suppress LH pulsatility during the following day. An earlier study demonstrated that E2 administration suppresses nocturnal increases in LH pulsatility during puberty. However, studies in adults suggest that P is the principal effector of LH pulse frequency slowing. It is unknown if P administration can suppresses nocturnal increases in LH pulsatility during puberty. To assess this further, we will study normal early to midpubertal girls. Volunteers will undergo a frequent sampling study in the GCRC. Oral P or placebo will be administered (according to randomization) at 1600 h and 2000 h. Frequent blood sampling from 1900-0900 h will allow assessment of overnight changes in LH pulse frequency after either P or placebo administration.