SLEEP-WAKE LH FREQUENCY IN PERIPUBERTAL GIRLS WITH AND WITHOUT HYPERANDROGENEMIA

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在青春期早期，LH频率通常在睡眠期间增加。相比之下，初步数据表明，肥胖女孩（通常是高雄激素血症）在青春期早期的白天和晚上表现出低LH频率;但在青春期中期，在白天和晚上迅速过渡到高LH频率。因此，我们假设，在青春期早期的女孩高雄激素血症，夜间LH（GnRH）的频率增加是不太突出的比在青春期早期的女孩没有高雄激素血症。我们建议进一步评估这一点，使用频繁的采样协议评估LH脉冲频率（采样发生在清醒和睡眠时）在青春期早期的女孩和不高雄激素血症。将通过分层混合效应ANCOVA模型分析数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During early puberty, LH frequency normally increases during sleep. In contrast, preliminary data suggest that obese girls (who are hyperandrogenemic in general) demonstrate low LH frequency during the day and night during early puberty; but at mid puberty rapidly transition to a high LH frequency during the day and night. Thus, we hypothesize that in early pubertal girls with hyperandrogenemia, overnight increases of LH (GnRH) frequency are less prominent than those observed in early pubertal girls without hyperandrogenemia. We propose to assess this further using a frequent sampling protocol for assessment of LH pulse frequency (with sampling occurring while awake and while asleep) in early pubertal girls with and without hyperandrogenemia. The data will be analyzed by way of hierarchical mixed-effects ANCOVA models.