EFFECT OF GLYCEMIC INDEX AND CEREAL FIBER ON VASCULAR ENDOTHELIAL FUNCTION

血糖指数和谷物纤维对血管内皮功能的影响

• 批准号: 7951481
• 负责人: Arthur Weltman
• 金额: $ 0.39万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951481
• 关键词: Adult; Adverse effects; Age; Analysis of Variance; Atherosclerosis; Blood Vessels; Cardiovascular system; Cereals; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Computer software; Development; Diet; Endothelium; Fiber; Funding; Glycemic Index; Grant; Human; Institution; Link; Measures; Mediating; Nitric Oxide; Research; Research Personnel; Resolution; Resources; Role; Source; Ultrasonography; United States National Institutes of Health; Vasodilator Agents; brachial artery; cardiovascular disorder risk; improved; in vivo Bioassay; mortality; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Flow-mediated dilation (FMD) of the brachial artery using high-resolution ultrasound is a well accepted non-invasive bioassay for in vivo endothelium-generated nitric oxide (NO) in humans. NO has been characterized as a potent vasodilator, but NO also has a considerable role in maintaining healthy endothelium and inhibiting key steps in the development, progression, and clinical manifestations of atherosclerosis. The postprandial state may be critical in the development of atherosclerosis. Diets high in cereal fiber have been linked to reduced risk of cardiovascular disease. Conversely, high-glycemic index (GI) diets have been linked to increased cardiovascular mortality. We postulate that the beneficial effect of cereal fiber on FMD is stronger than the potentially adverse effect of GI. Therefore, we hypothesize that breakfast meals high in cereal fiber will acutely improve FMD, regardless of GI. By contrast, we hypothesize that a high-GI breakfast meal that is low in cereal fiber will impair FMD. We also hypothesize that a breakfast meal that is low in both GI and cereal fiber will have no effect on postprandial FMD. Brachial artery flow-mediated dilation (FMD) will be assessed before and at 2 h and 4 h after each of four breakfast meals [(1) High-fiber, Low GI; (2) High-fiber, High-GI; (3) Low-fiber, Low-GI; (4) Low-fiber, High-GI] using high-resolution ultrasound and edge-detection software in healthy adults ages 18-64. Analysis of variance with repeated measures will be used to assess differences in FMD in response to the meal challenges.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 使用高分辨率超声对肱动脉进行血流介导扩张 (FMD) 是一种广为接受的非侵入性生物测定方法，用于检测人体体内内皮生成的一氧化氮 (NO)。 NO 被认为是一种有效的血管扩张剂，但 NO 在维持健康的内皮和抑制动脉粥样硬化的发生、进展和临床表现的关键步骤方面也具有相当大的作用。 餐后状态可能对动脉粥样硬化的发展至关重要。 富含谷物纤维的饮食与降低心血管疾病的风险有关。 相反，高血糖指数（GI）饮食与心血管死亡率增加有关。 我们假设谷物纤维对 FMD 的有益作用强于 GI 的潜在不利作用。 因此，我们假设，无论血糖指数如何，富含谷物纤维的早餐都会显着改善口蹄疫。 相比之下，我们假设谷类纤维含量低的高升糖指数早餐会损害口蹄疫。 我们还假设，低血糖指数和低谷类纤维的早餐对餐后口蹄疫没有影响。 将在四顿早餐之前以及之后 2 小时和 4 小时评估肱动脉血流介导的扩张 (FMD) [(1) 高纤维、低 GI； (2)高纤维、高GI； (3)低纤维、低GI； (4) 低纤维，高GI]在18-64岁的健康成年人中使用高分辨率超声和边缘检测软件。 重复测量的方差分析将用于评估 FMD 应对膳食挑战的差异。