Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status

运动强度对生长素释放肽的调节:肥胖和糖尿病前期状态的作用

基本信息

  • 批准号:
    10279846
  • 负责人:
  • 金额:
    $ 32.3万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-05 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary The goal of this proposal is to characterize the effects of two exercise “intensity doses” on total ghrelin, acyl ghrelin, and des-acyl ghrelin in lean and obese adults with and without prediabetes. Ghrelin (TG) is involved in the regulation of appetite, energy balance, glucose metabolism and insulin sensitivity. Ghrelin exists in the blood in a des-acyl form (DAG ~78% of TG), and in an acylated form (AG ~22% of TG). Despite being less abundant, AG is has multiple actions that promote energy storage, including stimulation of appetite, inhibition of insulin release from the pancreas, and increases in adiposity via a widely characterized growth hormone secretagogue receptor. Conversely, DAG often opposes AG promoting negative energy balance (appetite suppression and reduced fat mass (FM)) and improving insulin sensitivity, acting through a receptor not yet identified. The optimal ratios of TG, DAG, and AG are not clear. Likewise, there is a need for targeted approaches that can effectively manipulate these peptides to aid in the prevention and/or treatment of obesity, metabolic syndrome, prediabetes and type 2 diabetes. Exercise provides a unique therapeutic approach in the treatment of dysregulated ghrelin. Limited animal and human studies examining exercise and ghrelin release are mostly equivocal or only document TG and/or a single (e.g. AG) form of ghrelin. As DAG and AG can act synergistically, antagonistically, or have independent effects, the quantification of these peptides in response to exercise is critical to understanding the role of exercise on ghrelin release and ghrelin's exercise induced influence on overall glucose regulation and energy balance. Exercise intensity may be key, as exercise that elevates levels of lactate suppress AG and appetite post exercise. Here we propose to address this gap in knowledge by defining the role of acute exercise intensity, at doses above and below the lactate threshold, on TG, AG, and DAG release in lean and obese individuals with and without prediabetes. Specific Aim 1: Examine effects of exercise intensity on ghrelin, insulin, glucose and self-reported appetite. Hypothesis: Higher exercise intensity will result in differential effects on TG, AG, DAG, AG/DAG, insulin, and glucose AUC's, and appetite; affected by sex, obesity, abdominal visceral fat (AVF), and prediabetes status. Specific Aim 2: This is an exploratory aim using regression modeling to examine exercise-induced changes in ghrelin on glucose, insulin and appetite. Hypothesis: TG, AG, DAG and AG/DAG alterations will differentially predict changes in glucose metabolism, insulin sensitivity, and appetite. These alterations vary by sex, levels of obesity, AVF, and prediabetes. Results from this pilot/feasibility application will inform a larger submission that defines therapeutic exercise targets for TG, AG, and DAG, and examines the effects of individualized exercise training using precision exercise prescription techniques on ghrelin release.
项目总结

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Arthur Weltman其他文献

Arthur Weltman的其他文献

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{{ truncateString('Arthur Weltman', 18)}}的其他基金

Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status
运动强度对生长素释放肽的调节:肥胖和糖尿病前期状态的作用
  • 批准号:
    10443835
  • 财政年份:
    2021
  • 资助金额:
    $ 32.3万
  • 项目类别:
Modulation of Ghrelin Release by Exercise Intensity: The Role of Obesity and Prediabetes Status
运动强度对生长素释放肽的调节:肥胖和糖尿病前期状态的作用
  • 批准号:
    10661601
  • 财政年份:
    2021
  • 资助金额:
    $ 32.3万
  • 项目类别:
AEROBIC EX TRAINING ON ENDOTHELIAL FUNCTION IN AFRICAN AMERICAN, CAUCASIAN WOMEN
非裔美国、白人女性的内皮功能有氧极限训练
  • 批准号:
    8167176
  • 财政年份:
    2010
  • 资助金额:
    $ 32.3万
  • 项目类别:
HIGH-COMPLEX-HIGH-REFINED-CHO MEALS, AND LOW-CHO MEALS ON ENDOTHELIAL FUNCTION
高复合、高精制膳食和低膳食对内皮功能的影响
  • 批准号:
    7951480
  • 财政年份:
    2009
  • 资助金额:
    $ 32.3万
  • 项目类别:
EFFECTS OF CHO ON PERCEIVED EXERTION AND BLOOD LACTATE RESPONSE TO EXERCIS
CHO 对运动感知和血乳酸反应的影响
  • 批准号:
    7951509
  • 财政年份:
    2009
  • 资助金额:
    $ 32.3万
  • 项目类别:
EFFECT OF GLYCEMIC INDEX AND CEREAL FIBER ON VASCULAR ENDOTHELIAL FUNCTION
血糖指数和谷物纤维对血管内皮功能的影响
  • 批准号:
    7951481
  • 财政年份:
    2009
  • 资助金额:
    $ 32.3万
  • 项目类别:
AEROBIC EX TRAINING ON ENDOTHELIAL FUNCTION IN AFRICAN AMERICAN, CAUCASIAN WOMEN
非裔美国、白人女性的内皮功能有氧极限训练
  • 批准号:
    7951503
  • 财政年份:
    2009
  • 资助金额:
    $ 32.3万
  • 项目类别:
THE EFFECTS OF MODERATE- AND HIGH-INTENSITY EXERCISE ON VASCULAR FUNCTION
中、高强度运动对血管功能的影响
  • 批准号:
    7951492
  • 财政年份:
    2009
  • 资助金额:
    $ 32.3万
  • 项目类别:
EFFECTS OF CHO ON PERCEIVED EXERTION AND BLOOD LACTATE RESPONSE TO EXERCIS
CHO 对运动感知和血乳酸反应的影响
  • 批准号:
    7718601
  • 财政年份:
    2008
  • 资助金额:
    $ 32.3万
  • 项目类别:
AEROBIC EX TRAINING ON ENDOTHELIAL FUNCTION IN AFRICAN AMERICAN, CAUCASIAN WOMEN
非裔美国、白人女性的内皮功能有氧极限训练
  • 批准号:
    7718597
  • 财政年份:
    2008
  • 资助金额:
    $ 32.3万
  • 项目类别:

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