AEROBIC EX TRAINING ON ENDOTHELIAL FUNCTION IN AFRICAN AMERICAN, CAUCASIAN WOMEN

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究将评估12周有氧运动计划对绝经后妇女、非洲裔美国人和白人妇女血流介导的扩张的影响。它将采用2x2研究设计，其中受试者将在每个种族组内以2：1的比例分别随机分配至运动训练或无运动训练条件。将在基线和研究结束时测量FMD。具体的假设是，在有氧运动训练计划后，FMD的改善没有种族差异，但在非裔美国人受试者中，FMD的基线值较低。次要终点将评估这种运动训练对餐后代谢的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study will evaluate the effects of a 12-week aerobic exercise program on flow mediated dilation in postmenopausal women African American and Caucasian women. It will employ a 2x2 study design in which subjects will be randomized in a 2:1 ratio to either the exercise training or the no exercise training condition, respectively, within each racial group. FMD will be measured at baseline and at the conclusion of the study. The specific hypothesis is that there will be no racial differences in the improvement of FMD following an aerobic exercise training program, but there will be a lower baseline FMD in African American subjects. Secondary endpoints will evaluate the effect of this exercise training on postprandial metabolism.