AEROBIC EX TRAINING ON ENDOTHELIAL FUNCTION IN AFRICAN AMERICAN, CAUCASIAN WOMEN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项拟议的研究将评估为期12周的有氧运动计划对绝经后非裔美国人和高加索女性血流介导的扩张的影响。它将采用2x2研究设计，在每个种族组中，受试者将分别以2：1的比例随机分配到运动训练或不运动训练的条件下。FMD将在基线和研究结束时进行测量。具体的假设是，在有氧运动训练计划后，FMD的改善不会有种族差异，但非裔美国人受试者的基线FMD会更低。次级终点将评估这项运动训练对餐后代谢的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed study will evaluate the effects of a 12-week aerobic exercise program on flow mediated dilation in postmenopausal African American and Caucasian women. It will employ a 2x2 study design in which subjects will be randomized in a 2:1 ratio to either the exercise training or the no exercise training condition, respectively, within each racial group. FMD will be measured at baseline and at the conclusion of the study. The specific hypothesis is that there will be no racial differences in the improvement of FMD following an aerobic exercise training program, but there will be a lower baseline FMD in African American subjects. Secondary endpoints will evaluate the effect of this exercise training on postprandial metabolism.