DYNAMIC MECHANISMS OF PAIN MODULATION-SYSTEMIC CLONIDINE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们都经历过疼痛，然而，当我们感到疼痛时，我们对人体内到底发生了什么知之甚少。通过在不同条件下应用不同的痛感组合，并测量对它们的反应，我们可以间接观察神经系统(大脑、脊髓和神经)如何处理疼痛。通过了解疼痛的不同方面，我们希望更好地了解人类是如何体验疼痛的，以及我们可能采取哪些新的方法来治疗疼痛。 共有20人将作为研究对象参与研究。这一总数将包括20名正常的健康(无痛)受试者，他们将参加这个研究地点，地点在科格希尔实验室格雷大楼4087室和综合临床研究中心(GCRC)。所有参与者都没有慢性疼痛，不定期服用止痛药(止痛药)，在研究之前的两周内不会服用任何处方止痛药。 研究程序将需要4次访问。这将包括一段培训时间，以了解热探头如何工作，以及如何使用VAS估计疼痛。在每次访问期间，受试者将在其非优势前臂上接受从35摄氏度到51摄氏度不等的一系列热刺激。一次口服可乐定900微克/安慰剂将在访视1或访视3给予，以帮助描述支持抵消止痛现象的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We all have experienced pain, however, very little is known about exactly what goes on in the human body while we feel pain. By applying different combinations of painful sensations under different conditions, and measuring the responses to them, we can make indirect observations as to how the nervous system (brain, spinal cord, and nerves) processes pain. By finding out how different aspects of pain feel, we hope to get a better understanding of how humans experience pain and what new approaches we may take to treat pain. A total of 20 people will be involved as subjects for the research study. This total will include 20 normal healthy (pain-free) subjects who will participate at this research site in the Coghill Lab, Gray building, room 4087 and at the General Clinical Research Center (GCRC). All participants will be without chronic pain, not taking analgesics (pain medications) regularly and will not have taken any prescription pain medications for 2 weeks before the study. The study procedures will require 4 visits. This will include a training period to learn how the heat probe works and how to estimate the pain using the VAS. The subject will be given a series of thermal stimulations ranging from 35 degrees C to 51 degrees C on his/her non-dominant forearm during each of the visits. A single oral dose of clonidine 900 ug/placebo will be administered on visit 1 or visit 3 to help delineate the mechanism that supports the phenomenon of offset analgesia.