DYNAMIC MECHANISMS OF PAIN MODULATION-SYSTEMIC CLONIDINE

疼痛调节的动态机制——系统性可乐定

• 批准号: 7951386
• 负责人: Robert C Coghill
• 金额: $ 0.1万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951386
• 关键词: Absence of pain sensation; Analgesics; Brain; Clinical Research; Clonidine; Computer Retrieval of Information on Scientific Projects Database; Dose; Esthesia; Forearm; Funding; Grant; Gray unit of radiation dose; Heating; Human; Human body; Institution; Learning; Measures; Nerve; Oral; Pain; Pain-Free; Participant; Placebos; Procedures; Process; Research; Research Personnel; Resources; Series; Site; Source; Spinal Cord; Training; United States National Institutes of Health; Visit; Work; chronic pain; experience; novel strategies; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We all have experienced pain, however, very little is known about exactly what goes on in the human body while we feel pain. By applying different combinations of painful sensations under different conditions, and measuring the responses to them, we can make indirect observations as to how the nervous system (brain, spinal cord, and nerves) processes pain. By finding out how different aspects of pain feel, we hope to get a better understanding of how humans experience pain and what new approaches we may take to treat pain. A total of 20 people will be involved as subjects for the research study. This total will include 20 normal healthy (pain-free) subjects who will participate at this research site in the Coghill Lab, Gray building, room 4087 and at the General Clinical Research Center (GCRC). All participants will be without chronic pain, not taking analgesics (pain medications) regularly and will not have taken any prescription pain medications for 2 weeks before the study. The study procedures will require 4 visits. This will include a training period to learn how the heat probe works and how to estimate the pain using the VAS. The subject will be given a series of thermal stimulations ranging from 35 degrees C to 51 degrees C on his/her non-dominant forearm during each of the visits. A single oral dose of clonidine 900 ug/placebo will be administered on visit 1 or visit 3 to help delineate the mechanism that supports the phenomenon of offset analgesia.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们都经历过疼痛，然而，我们对感到疼痛时人体到底发生了什么却知之甚少。通过在不同条件下应用不同的疼痛感觉组合，并测量对它们的反应，我们可以间接观察神经系统（大脑、脊髓和神经）如何处理疼痛。通过了解疼痛的不同方面的感觉，我们希望更好地了解人类如何体验疼痛以及我们可以采取哪些新方法来治疗疼痛。 共有20人将作为研究对象参与。这一总数将包括 20 名正常健康（无痛）受试者，他们将参加位于格雷大楼 4087 室 Coghill 实验室和普通临床研究中心 (GCRC) 的研究地点。所有参与者都不会出现慢性疼痛，不会定期服用镇痛药（止痛药），并且在研究前 2 周内不会服用任何处方止痛药。 研究程序需要 4 次就诊。这将包括一个培训期，以学习热探针的工作原理以及如何使用 VAS 来估计疼痛。每次访问期间，将在受试者的非优势前臂上给予一系列 35 摄氏度至 51 摄氏度的热刺激。将在第 1 次或第 3 次访视时给予单次口服剂量的可乐定 900 ug/安慰剂，以帮助描述支持抵消镇痛现象的机制。