CORRELATION OF MATRIX METALLOPROTEINASE AND FUNCTIONAL OUTCOME FOLLOWING TRAUMA

基质金属蛋白酶与创伤后功能结果的相关性

• 批准号: 7952063
• 负责人: GARY ROSENBERG
• 金额: $ 0.21万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7952063
• 关键词: Accident and Emergency department; Animals; Area; Brain; Brain Injuries; Cerebrospinal Fluid; Chemicals; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Inflammatory; Inflammatory Response; Institution; Lead; Liquid substance; Matrix Metalloproteinases; New Mexico; Patients; Reaction; Research; Research Personnel; Resources; Source; Spinal Cord; Swelling; Trauma; Traumatic Brain Injury; United States; United States National Institutes of Health; Universities; brain tissue; experience; functional outcomes; injured; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is looking at whether an increase in certain chemicals that occur in the cerebrospinal fluid [CSF- the fluid that surrounds the brain and spinal cord] is related to the how well a patient does neurologically following a traumatic brain injury. Approximately 1.4 million people end up in emergency rooms across the United States with a Traumatic Brain Injury [TBI] every year. Many of these people will experience some degree of permanent brain injury. Some studies have suggested that there is an inflammatory response that occurs around the area of the brain that has been injured after the initial brain injury. This response may lead to additional brain tissue being injured over the next few weeks. In this study we are examining the chemicals that occur during this inflammatory reaction called matrix metalloproteinases [MMP] which have been shown in animal studies to allow excess swelling in the brain to occur.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究正在研究脑脊液中某些化学物质的增加是否与创伤性脑损伤后患者的神经功能状况有关。 美国每年约有140万人因创伤性脑损伤（TBI）而进入急诊室。这些人中的许多人会经历某种程度的永久性脑损伤。一些研究表明，在最初的脑损伤后，在脑损伤区域周围发生了炎症反应。这种反应可能会导致更多的脑组织在未来几周内受伤。在这项研究中，我们正在研究在这种炎症反应中发生的化学物质，称为基质金属蛋白酶[MMP]，在动物研究中已显示出允许大脑过度肿胀。