CORRELATION OF MATRIX METALLOPROTEINASE AND FUNCTIONAL OUTCOME FOLLOWING TRAUMA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究正在研究脑脊液[脑脊液]中某些化学物质的增加是否与患者在创伤性脑损伤后的神经学表现有关。 美国每年约有140万人因创伤性脑损伤而被送进急诊室。这些人中的许多人将经历某种程度的永久性脑损伤。一些研究表明，在最初的脑损伤后，脑部受损区域周围发生了炎症反应。这种反应可能会在接下来的几周内导致更多的脑组织受损。在这项研究中，我们正在研究在这种炎症反应中发生的称为基质金属蛋白酶[MMP]的化学物质，动物研究表明，这种化学物质允许大脑发生过度肿胀。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is looking at whether an increase in certain chemicals that occur in the cerebrospinal fluid [CSF- the fluid that surrounds the brain and spinal cord] is related to the how well a patient does neurologically following a traumatic brain injury. Approximately 1.4 million people end up in emergency rooms across the United States with a Traumatic Brain Injury [TBI] every year. Many of these people will experience some degree of permanent brain injury. Some studies have suggested that there is an inflammatory response that occurs around the area of the brain that has been injured after the initial brain injury. This response may lead to additional brain tissue being injured over the next few weeks. In this study we are examining the chemicals that occur during this inflammatory reaction called matrix metalloproteinases [MMP] which have been shown in animal studies to allow excess swelling in the brain to occur.