MATRIX METALLAPROTENINASES AS BIOCHEMICAL MARKERS IN VASCULAR DEMENTIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究建议检测痴呆症患者的脑脊液和脑磁共振波谱。具体地说，特定酶(例如，基质金属蛋白酶-2)的活性将与指示神经轴突损伤和胶质增生(NAA、胆碱)的神经代谢物相关。根据先前的观察，我们假设这些标记物将存在于血管损伤导致或导致痴呆的患者中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The present study proposes to examine CSF and brain magnetic resonance spectroscopy in dementia patients. Specifically, the activity of specific enzymes (e.g., MMP-2) will be correlated with neurometabolites that indicate neuro-axonal injury and gliosis (NAA, Choline). Based on previous observations, we hypothesize that these markers will be present in patients for whom vascular injury contributes to or causes their dementia.