MATRIX METALLAPROTENINASES AS BIOCHEMICAL MARKERS IN VASCULAR DEMENTIA

基质金属蛋白酶作为血管性痴呆的生化标志物

• 批准号: 7606887
• 负责人: GARY ROSENBERG
• 金额: $ 1.03万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606887
• 关键词: Biochemical Markers; Blood Vessels; Brain; Choline; Computer Retrieval of Information on Scientific Projects Database; Dementia; Enzymes; Funding; Gelatinase A; Gliosis; Grant; Injury; Institution; Magnetic Resonance Spectroscopy; Patients; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Vascular Dementia; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The present study proposes to examine CSF and brain magnetic resonance spectroscopy in dementia patients. Specifically, the activity of specific enzymes (e.g., MMP-2) will be correlated with neurometabolites that indicate neuro-axonal injury and gliosis (NAA, Choline). Based on previous observations, we hypothesize that these markers will be present in patients for whom vascular injury contributes to or causes their dementia.

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