AGE AND SYMPATHETIC COTRANSMITTER FUNCTION IN HUMAN SKIN

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 本研究拟系统地探讨交感神经递质在人体皮肤中的储存、释放和受体结合的神经元和血管机制。 此外，我们打算在老年受试者中外源性补充BH 4和抗坏血酸，以潜在地改善血管收缩功能。 拟议的研究将是用于即将到来的竞争性NIH R 01更新的试点工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our proposed studies intend to systematically investigate neuronal and vascular mechanisms of sympathetic neurotransmitter storage, release, and receptor binding in human skin. Also, we intend to supplement BH4 and ascorbate exogenously in aged subjects to potentially ameliorate vasoconstrictor function. The proposed studies will be pilot work used for an upcoming competitive NIH R01 renewal.