POLYMODAL NEUROIMAGING IN GENETICALLY DETERMINED PARKINSON'S DISEASE

多模式神经影像在遗传决定的帕金森病中的应用

• 批准号: 7951950
• 负责人: DAVID EIDELBERG
• 金额: $ 0.15万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951950
• 关键词: Brain; Cerebrum; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Dopamine; Functional disorder; Funding; Grant; Institution; LRRK2 gene; Magnetic Resonance Imaging; Measures; Parkinson Disease; Patients; Pattern; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; Staging; Structure; United States National Institutes of Health; brain metabolism; glucose metabolism; mutation carrier; neuroimaging; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this application we plan to investigate the pathophysiology and pathoanatomy in genetically determined and idiopathic Parkinson's disease (PD) in different stages of PD (asymptomatic and symptomatic stage). We propose the following aims: First, using positron emission tomography (PET), to measure regional cerebral dopamine concentration and glucose metabolism in patients with genetically determined (LRRK2 mutation carriers) and idiopathic PD and normal volunteers in order to determine the specific abnormalities of brain metabolism in PD. Second, using magnetic-resonance-imaging (MRI), to investigate structural patterns in patients with genetically determined (LRRK2 mutation carriers) and idiopathic PD and normal volunteers in order to determine the specific abnormalities of brain structure in PD.

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