EFFECTS OF BRANCHED CHAIN AMINO ACIDS ON DOPAMINE FUNCTION IN HEALTHY SUBJECTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项初步研究将评估支链氨基酸(BCAA)对10名18-40岁健康男性受试者的多巴胺能效应。在口服支链氨基酸混合物后，将通过血浆儿茶酚胺(HVA和MHPG)和催乳素水平以及多巴胺D2受体的可用性(用[11C]-拉氯普利和正电子发射断层扫描进行评估)来衡量对多巴胺活性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pilot study will assess the dopaminergic effects of Branched-Chain Amino Acids (BCAA) in ten 18-40 year old male healthy subjects. The effects on dopamine activity will be measured with plasma catecholamine (HVA and MHPG) and prolactin levels, and dopamine D2 receptor availability (assessed with [11C]-raclopride and Positron Emission Tomography) following the oral administration of a BCAA mixture.