EFFECTS OF BRANCHED CHAIN AMINO ACIDS ON DOPAMINE FUNCTION IN HEALTHY SUBJECTS

支链氨基酸对健康受试者多巴胺功能的影响

• 批准号: 7719279
• 负责人: SERGE SEVY
• 金额: $ 2.21万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719279
• 关键词: Branched-Chain Amino Acids; Catecholamines; Computer Retrieval of Information on Scientific Projects Database; Dopamine; Dopamine D2 Receptor; Funding; Grant; Institution; Measures; Methoxyhydroxyphenylglycol; Oral Administration; Pilot Projects; Plasma; Positron-Emission Tomography; Prolactin; Raclopride; Research; Research Personnel; Resources; Source; United States National Institutes of Health; homovanillate; male

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pilot study will assess the dopaminergic effects of Branched-Chain Amino Acids (BCAA) in ten 18-40 year old male healthy subjects. The effects on dopamine activity will be measured with plasma catecholamine (HVA and MHPG) and prolactin levels, and dopamine D2 receptor availability (assessed with [11C]-raclopride and positron emission tomography) following the oral administration of a BCAA mixture.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该试点研究将评估支链氨基酸（BCAA）对10名18-40岁男性健康受试者的多巴胺能影响。口服BCAA混合物后，将通过血浆儿茶酚胺（HVA和MHPG）和催乳素水平以及多巴胺D2受体利用率（采用[11 C]-雷氯必利和正电子发射断层扫描评估）测量对多巴胺活性的影响。