EFFECTS OF BRANCHED CHAIN AMINO ACIDS ON DOPAMINE FUNCTION IN HEALTHY SUBJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 初步研究将评估支链氨基酸（BCAA）在10名18-40岁男性健康受试者中的多巴胺能效应。口服BCAA混合物后，将通过血浆儿茶酚胺（HVA和MHPG）和催乳素水平以及多巴胺D2受体利用率（采用[11 C]-雷氯必利和正电子发射断层扫描评估）测量对多巴胺活性的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pilot study will assess the dopaminergic effects of Branched-Chain Amino Acids (BCAA) in ten 18-40 year old male healthy subjects. The effects on dopamine activity will be measured with plasma catecholamine (HVA and MHPG) and prolactin levels, and dopamine D2 receptor availability (assessed with [11C]-raclopride and positron emission tomography) following the oral administration of a BCAA mixture.