DOPAMINERGIC FUNCTION IN YOUNG CANNABIS ABUSERS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这项R21探索性/发展资助中提出的研究将比较15名18-21岁的受试者，他们在青春期有长期大麻暴露史（大麻使用的持续时间必须在18岁之前超过一年），并接受了住宅康复计划（Aurora Concept，Incorporated），15名年龄和性别匹配的健康受试者。将测量局部葡萄糖代谢（用[18 F]-FDG和PET评估）和多巴胺D2受体可用性（用[11 C]-雷氯必利和PET评估）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study proposed in this R21 exploratory/developmental grant will compare fifteen 18-21 year old subjects with a history of prolonged cannabis exposure in adolescence (duration of cannabis use must be more than one year before age 18) and admitted to a residential rehabilitation program (Aurora Concept, Incorporated), with fifteen age- and sex-matched healthy subjects. Regional glucose metabolism (assessed with [18F]-FDG and PET) and dopamine D2 receptor availability (assessed with [11C]-raclopride and PET) will be measured.