DYNAMICS OF PROTEIN RNASE A & WATER-PROTEIN INTERACT AT DIFFERENT TEMPERATURES

蛋白质 RNA 酶 A 的动力学

基本信息

  • 批准号:
    7955570
  • 负责人:
  • 金额:
    $ 2.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2009
  • 资助国家:
    美国
  • 起止时间:
    2009-07-01 至 2010-06-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proteins are known to undergo `glass transition` when subjected to temperature variations at ambient pressure. This transition involves dynamics of protein molecules and their enzymatic activity. From crystallographic Debye-Waller factors and protein crystal structures, the relation between protein dynamics and enzymatic activity was established. Though it is widely accepted that protein glass transition is highly related to the hydration water, the exact mechanisms are still lacking. Therefore, our aim is to understand these exact mechanisms and the interactions between water and protein molecules. In the first step of the study, we will grow two kinds of RNase A crystals from two different mother liquors which impose two different solvent environments to protein molecules. The complete dataset for these crystals will be collected at 9 temperature points ranging from 98 K to 320 K (one complete dataset for each point). These two kinds of crystals are expected to exhibit different glass transition behaviors due to different solvent environments, which will confirm the proposed relation between protein dynamics and water properties. The previous experiments showed our RNase A crystals have good diffraction quality.
这个子项目是众多研究子项目之一

项目成果

期刊论文数量(0)
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SOL M GRUNER其他文献

SOL M GRUNER的其他文献

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{{ truncateString('SOL M GRUNER', 18)}}的其他基金

MACCHESS PROGRAM FOR PRESSURE CRYOCOOLING AND RELATED PROCEDURES
压力低温冷却的 MACCHESS 程序及相关程序
  • 批准号:
    8363544
  • 财政年份:
    2011
  • 资助金额:
    $ 2.22万
  • 项目类别:
PRESSURE-INDUCED PROTEIN GLASS TRANSITION AND WATER-PROTEIN INTERACT
压力诱导的蛋白质玻璃化转变和水-蛋白质相互作用
  • 批准号:
    7955589
  • 财政年份:
    2009
  • 资助金额:
    $ 2.22万
  • 项目类别:
MACCHESS PROGRAM FOR MICROCRYSTALLOGRAPHY/MEMBRANE PROTEIN CRYSTALS
微晶学/膜蛋白晶体的 MACCHESS 程序
  • 批准号:
    7955550
  • 财政年份:
    2009
  • 资助金额:
    $ 2.22万
  • 项目类别:
MACCHESS PROGRAM FOR MICROCRYSTALLOGRAPHY/MEMBRANE PROTEIN CRYSTALS
微晶学/膜蛋白晶体的 MACCHESS 程序
  • 批准号:
    7721302
  • 财政年份:
    2008
  • 资助金额:
    $ 2.22万
  • 项目类别:
HIGH PRESSURE CRYOCOOLING IN PREPARATION FOR 70S RIBOSOME CRYSTALS
高压低温冷却制备 70S 核糖体晶体
  • 批准号:
    7721303
  • 财政年份:
    2008
  • 资助金额:
    $ 2.22万
  • 项目类别:
DYNAMICS OF PROTEIN RNASE A & WATER-PROTEIN INTERACT AT DIFFERENT TEMPERATURES
蛋白质 RNA 酶 A 的动力学
  • 批准号:
    7721339
  • 财政年份:
    2008
  • 资助金额:
    $ 2.22万
  • 项目类别:
PROPRIETARY
所有权
  • 批准号:
    7721291
  • 财政年份:
    2008
  • 资助金额:
    $ 2.22万
  • 项目类别:
PIXEL ARRAY DETECTOR DEVELOPMENT
像素阵列探测器开发
  • 批准号:
    7721338
  • 财政年份:
    2008
  • 资助金额:
    $ 2.22万
  • 项目类别:
PROPRIETARY
所有权
  • 批准号:
    7598539
  • 财政年份:
    2007
  • 资助金额:
    $ 2.22万
  • 项目类别:
HIGH PRESSURE CRYOCOOLING AND RADIATION DAMAGE
高压低温冷却和辐射损伤
  • 批准号:
    7598558
  • 财政年份:
    2007
  • 资助金额:
    $ 2.22万
  • 项目类别:
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