CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 7956797
• 负责人: JONATHAN A DOORN
• 金额: $ 1.61万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956797
• 关键词: Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Event; Flow Cytometry; Funding; Grant; Institution; Noise; Phase; Raman Spectrum Analysis; Research; Research Personnel; Resolution; Resources; Signal Transduction; Sorting - Cell Movement; Source; Spectrum Analysis; Surface; System; United States National Institutes of Health; Work; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 表面增强拉曼光谱(SERS)纳米颗粒具有明显的光谱带，可用于生物医学诊断。特别是，表面增强拉曼散射颗粒已经成为流式细胞术的有希望的信标。由于SERS粒子具有明显的拉曼光谱和高信噪比，它们有可能被用于多路分析，这些分析不仅需要大的动态范围，而且需要窄的光谱带宽来区分事件。我们正在致力于使用LANL开发的流式细胞仪系统来表征SERS颗粒，包括光谱、相敏和高分辨率仪器。