CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 8361778
• 负责人: JONATHAN A DOORN
• 金额: $ 1.12万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8361778
• 关键词: Biological Assay; Diagnostic; Event; Flow Cytometry; Funding; Grant; National Center for Research Resources; Noise; Phase; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Resolution; Resources; Signal Transduction; Sorting - Cell Movement; Source; Surface; System; United States National Institutes of Health; Work; cost; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 表面增强拉曼光谱（Sers）纳米颗粒具有可用于生物医学诊断的不同光谱带。 特别是，Sers颗粒已经成为流式细胞术的有前途的信标。 由于Sers颗粒具有高信噪比的独特拉曼光谱，因此它们有可能用于不仅需要大的动态范围而且需要窄的光谱带宽来区分事件的多路复用测定。 我们正在努力使用LANL开发的流式细胞仪系统对Sers颗粒进行表征，包括光谱，相敏和高分辨率仪器。