Human Exposure and Toxic Responses to Biomaterials

人体对生物材料的接触和毒性反应

• 批准号: 8399340
• 负责人: JONATHAN A DOORN
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8399340
• 关键词: Address; American; Area; Award; Biocompatible Materials; Biology; Chemicals; Chemistry; DNA; Development; Disease; Education; Educational workshop; Engineering; Environment; Environmental Exposure; Environmental Health; Event; Exposure to; Feedback; Fostering; Funding; Future; Genomic Instability; Health; Human; Knowledge; Lesion; Link; Malignant Neoplasms; Medicine; Mission; Molecular; Mutation; Nanotechnology; National Institute of Environmental Health Sciences; Paper; Pharmaceutical Preparations; Philadelphia; Postdoctoral Fellow; Prevention; Process; Reactive Oxygen Species; Request for Applications; Research; Research Personnel; Role; Science; Scientist; Societies; Students; Toxic effect; Toxicology; Training; Travel; Work; base; design; environmental agent; exposed human population; interdisciplinary approach; interest; meetings; member; nanotoxicology; posters; professor; programs; repaired; response; structural biology; symposium; toxicant

DESCRIPTION (provided by applicant): This application requests support for programming of the Division of Chemical Toxicology of the American Chemical Society (ACS) at its 244th National Meeting and Exposition in Philadelphia, PA from Sunday, August 19, 2012 to Wednesday, August 22, 2012. A unique feature of this ACS meeting is the broad theme of the entire meeting, "Materials for Health and Medicine", which aligns highlighted events across the programming of all ACS divisions. The mission of the ACS Division of Chemical Toxicology is to promote the understanding of chemical mechanisms that contribute to disease processes and the toxicity of environmental agents, biomaterials, drugs and endogenous chemicals. The Division integrates work in chemistry, chemical biology, structural biology, toxicology, environmental health sciences and disease mechanisms. The global theme "Materials for Health and Medicine" aligns closely with the core focus areas of the Division of Chemical Toxicology and thus provides a backdrop that reinforces programming in the Division and related content particularly for students and postdoctoral fellows. Three interrelated symposia are planned around the central theme "Human Exposure and Toxic Responses to Biomaterials" and include invited talks by a diverse group of leading established and up-and-coming scientists. The two symposia for which support is requested have especially strong relevance to the mission of the NIEHS. The first (Symposium #2) is entitled "Genome Instability" and addresses molecular mechanisms by which electrophiles and reactive oxygen species cause lesions and mutations to DNA and the resulting repair processes. The second (Symposium #3) is entitled "Harnessing Nanotechnology for Human Health and Environment" and focuses on the emerging field of nanotechnology and health implications for such engineered materials (i.e., nanotoxicology). A proffered paper session and a Young Investigators Symposium offer opportunities for young scientists in training to present their primary contributions and receive critical feedback from senior experts. Other highlights are a keynote awards symposium and a professional development workshop. Overall, the ACS TOXI meeting is designed to disseminate current information regarding toxicants and disease and provide young scientists with a rich training environment. PUBLIC HEALTH RELEVANCE: Effective prevention and treatment of environmentally-related diseases require an understanding of underlying mechanisms that link environmental exposures to disease mechanisms. This meeting of the Division of Chemical Toxicology of the American Chemical Society will explore the chemical mechanisms for disease processes including cancer; specifically, the sponsored symposia will feature cutting edge research on the impact of biomaterials (nanotechnology and nanotoxicology), environmental agents, drugs and endogenous compounds on human health and disease.

描述(由申请人提供)：本申请请求在2012年8月19日(星期日)至2012年8月22日(星期三)在宾夕法尼亚州费城举行的第244次全国会议和博览会上支持美国化学学会(ACS)化学毒理学分部的规划。本次会议的一个独特之处是，整个会议的主题是“健康和医学材料”，这一主题将所有ACS部门的重点活动结合在一起。美国化学毒理学协会化学毒理学分部的使命是促进对导致疾病过程的化学机制以及环境制剂、生物材料、药物和内源性化学物质的毒性的了解。该司综合了化学、化学生物学、结构生物学、毒理学、环境卫生科学和疾病机制方面的工作。全球主题“保健和医药材料”与化学毒理学司的核心重点领域密切一致，从而提供了一个背景，加强了该司的方案编制和相关内容，特别是为学生和博士后研究员。围绕“人类对生物材料的暴露和毒性反应”这一中心主题，计划举办三个相互关联的研讨会，其中包括由知名和后起之秀科学家组成的不同团体的特邀演讲。请求提供支助的两个专题讨论会与NIEHS的使命特别相关。第一次会议(第2次研讨会)题为“基因组不稳定”，讨论了亲电体和活性氧物种导致DNA损伤和突变以及由此产生的修复过程的分子机制。第二个专题讨论会(第3号专题讨论会)题为“利用纳米技术促进人类健康和环境”，重点是新兴的纳米技术领域和这种工程材料对健康的影响(即纳米毒理学)。提供的论文会议和青年调查人员专题讨论会为正在接受培训的青年科学家提供机会，介绍他们的主要贡献，并从资深专家那里获得批判性反馈。其他亮点还包括主旨奖项研讨会和专业发展研讨会。总体而言，ACS Toxi会议旨在传播有关毒物和疾病的最新信息，并为年轻科学家提供丰富的培训环境。 公共卫生相关性：有效预防和治疗与环境有关的疾病需要了解将环境暴露与疾病机制联系起来的基本机制。美国化学学会化学毒理学分会的这次会议将探讨包括癌症在内的疾病过程的化学机制；特别是，赞助的研讨会将突出生物材料(纳米技术和纳米毒理学)、环境制剂、药物和内源性化合物对人类健康和疾病的影响的前沿研究。