CHARACTERIZATION AND APPLICATIONS OF SERS NANOPARTICLES

SERS纳米粒子的表征及应用

• 批准号: 8169414
• 负责人: JONATHAN A DOORN
• 金额: $ 1.67万
• 依托单位: LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169414
• 关键词: Biological Assay; Computer Retrieval of Information on Scientific Projects Database; Diagnostic; Event; Flow Cytometry; Funding; Grant; Institution; Noise; Phase; Raman Spectrum Analysis; Research; Research Personnel; Resolution; Resources; Signal Transduction; Source; Spectrum Analysis; Surface; System; United States National Institutes of Health; Work; instrument; nanoparticle; particle

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Surface enhanced Raman spectroscopy (SERS) nanoparticles have distinct spectral bands that can be exploited for biomedical diagnostics. In particular, SERS particles have emerged as promising beacons for flow cytometry. Because SERS particles have distinct Raman spectra with high signal to noise, they have the potential to be used for multiplexing assays that require not only great dynamic range but also narrow spectral bandwidths to discriminate between events . We are working towards the characterization of SERS particles using flow cytometry systems developed at LANL, including the spectral, phase-sensitive and high-resolution instruments.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 表面增强拉曼光谱（Sers）纳米颗粒具有可用于生物医学诊断的不同光谱带。 特别是，Sers颗粒已经成为流式细胞术的有前途的信标。 由于Sers颗粒具有高信噪比的独特拉曼光谱，因此它们有可能用于不仅需要大的动态范围而且需要窄的光谱带宽来区分事件的多路复用测定。 我们正在努力使用LANL开发的流式细胞仪系统对Sers颗粒进行表征，包括光谱，相敏和高分辨率仪器。