SPECTROSCOPY OF HUMAN BRAIN AT 7T

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 质子磁共振波谱(1H-MRS)为在体无创性测量人脑中的代谢物提供了有效的工具。高场MRS得益于增加的化学位移色散和信号增益。由于标量耦合效应和大分子基线信号产生的光谱复杂性，标准的1H-MRS往往难以准确测量几种临床上重要的低丰度代谢物，即使在7T也是如此。这项研究的目的是开发MRS技术，为7T和3T的甘氨酸、丝氨酸、N-乙酰天冬氨酸(NAAG)、谷氨酰胺、g-氨基丁酸等的检测提供改进的代谢物间分辨能力。MRS研究的重点是前额叶和海马区，这些区域在实验上具有挑战性，但与几种神经精神障碍有很高的相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proton magnetic resonance spectroscopy (1H-MRS) provides an effective tool for measuring metabolites in the human brain noninvasively in vivo. High-field MRS benefits from the increased chemical shift dispersion and signal gain. Precise measurement of several clinically-important, low-abundance metabolites by standard 1H-MRS is often elusive even at 7T, due to the spectroscopic complexities arising from the scalar coupling effects and macromolecule baseline signals. The objectives of the research are to develop MRS techniques that provide improved inter-metabolite discrimination for detection of glycine, serine, N-acetylaspartyl-glutamate (NAAG), glutamine, g-aminobutyric acid, etc., at both 7T and 3T. The MRS studies focus on prefrontal and hippocampal regions which are experimentally challenging but have high relevance to several neuropsychiatric disorders.