SPECTROSCOPY OF HUMAN BRAIN AT 7T

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 质子磁共振波谱（1H-MRS）提供了一种有效的工具，测量代谢物在人脑中的非侵入性体内。 高场MRS受益于增加的化学位移色散和信号增益。 由于标量耦合效应和大分子基线信号引起的光谱复杂性，即使在7 T下，通过标准1H-MRS对几种临床重要的低丰度代谢物的精确测量也常常是难以实现的。 本研究的目的是开发MRS技术，该技术提供用于检测甘氨酸、丝氨酸、N-乙酰基-谷氨酸（NAAG）、谷氨酰胺、g-氨基丁酸等的改进的代谢物间区分，在7 T和3 T下。 磁共振波谱研究的重点是前额叶和海马区，这是实验上的挑战，但有高度的相关性，一些神经精神疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proton magnetic resonance spectroscopy (1H-MRS) provides an effective tool for measuring metabolites in the human brain noninvasively in vivo. High-field MRS benefits from the increased chemical shift dispersion and signal gain. Precise measurement of several clinically-important, low-abundance metabolites by standard 1H-MRS is often elusive even at 7T, due to the spectroscopic complexities arising from the scalar coupling effects and macromolecule baseline signals. The objectives of the research are to develop MRS techniques that provide improved inter-metabolite discrimination for detection of glycine, serine, N-acetylaspartyl-glutamate (NAAG), glutamine, g-aminobutyric acid, etc., at both 7T and 3T. The MRS studies focus on prefrontal and hippocampal regions which are experimentally challenging but have high relevance to several neuropsychiatric disorders.