SPECTROSCOPY OF HUMAN BRAIN AT 7T

7T 下的人脑光谱

• 批准号: 7956949
• 负责人: Changho Choi
• 金额: $ 1.78万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7956949
• 关键词: Aminobutyric Acids; Brain; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Coupling; Detection; Discrimination; Disease; Funding; Glutamates; Glutamine; Glycine; Grant; Hippocampus (Brain); Human; Institution; Magnetic Resonance Spectroscopy; Measurement; Measures; Metabolism; Protons; Research; Research Personnel; Resources; Serine; Signal Transduction; Source; Spectrum Analysis; Techniques; United States National Institutes of Health; improved; in vivo; macromolecule; neuropsychiatry; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proton magnetic resonance spectroscopy (1H-MRS) provides an effective tool for measuring metabolites in the human brain noninvasively in vivo. High-field MRS benefits from the increased chemical shift dispersion and signal gain. Precise measurement of several clinically-important, low-abundance metabolites by standard 1H-MRS is often elusive even at 7T, due to the spectroscopic complexities arising from the scalar coupling effects and macromolecule baseline signals. The objectives of the research are to develop MRS techniques that provide improved inter-metabolite discrimination for detection of glycine, serine, N-acetylaspartyl-glutamate (NAAG), glutamine, g-aminobutyric acid, etc., at both 7T and 3T. The MRS studies focus on prefrontal and hippocampal regions which are experimentally challenging but have high relevance to several neuropsychiatric disorders.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 质子磁共振波谱（1H-MRS）为体内无创测量人脑代谢物提供了有效的工具。 高场 MRS 受益于化学位移色散和信号增益的增加。 由于标量耦合效应和大分子基线信号引起的光谱复杂性，即使在 7T 下，通过标准 1H-MRS 精确测量几种临床上重要的低丰度代谢物通常也难以实现。 该研究的目标是开发 MRS 技术，以改进代谢物间区分，以在 7T 和 3T 下检测甘氨酸、丝氨酸、N-乙酰天冬氨酰谷氨酸 (NAAG)、谷氨酰胺、g-氨基丁酸等。 MRS 研究重点关注前额叶和海马区域，这些区域在实验上具有挑战性，但与多种神经精神疾病高度相关。