Novel High-field MRS Study of CNS Neurotransmitter Function in Schizophrenia

精神分裂症中枢神经递质功能的新型高场 MRS 研究

基本信息

  • 批准号:
    8192034
  • 负责人:
  • 金额:
    $ 23.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-08 至 2013-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Convergent lines of evidence indicate that schizophrenia may involve alterations in glutamate neurotransmission. While human postmortem and animal-model studies have been critical in achieving this understanding, any definitive testing of existing models requires in vivo demonstration in humans of neurotransmitter system pathology. Glutamatergic hypofunction in schizophrenia may be reflected by alterations in brain metabolite levels, as suggested in prior studies. In this exploratory grant request, we aim to create novel methodologies to measure glutamate-related neurochemical profiles in schizophrenia using proton magnetic resonance spectroscopy (MRS) at 7 T, taking advantage of the high field benefits of signal gain and spectral resolution enhancement. We have developed new 7 T MRS methods recently that allow precise measurements of several experimentally-challenging brain metabolites, including glutamate, glutamine, GABA, glycine, N-acetylaspartyl-glutamate, glutathione, and myo-inositol, which were achieved by means of echo time optimization of standard MRS sequences. We will measure the concentrations of these brain metabolites, in addition to other major signals in brain MRS (i.e., N-acetylaspartate, creatine and choline), in anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) in volunteers with schizophrenia (SZ) and normal controls (NC). ACC and DLPFC are the brain regions most critically involved in SZ and thus this study will create a focus coincident with a number of prior studies. We will enroll 40 SZ volunteers (20 on- antipsychotic drugs, SZ-ON, and 20 off-medication, SZ-OFF) and 20 age-matched controls. Each patient will undergo a complete workup with a research diagnosis (SCID) interview, cognitive characterization (MATRIC Battery), and symptom assessment (PANSS). MRS data from the groups will be analyzed for differences, then correlated with patient characteristics. We will test whether any of the MRS group differences are associated with specific phenotypes in schizophrenia. Test-retest MRS scans will be conducted with a 2-week interval on 15 subjects (5 SZ-ON, 5 SZ-OFF, and 5 controls) in order to assess the reproducibility of the MRS data. PUBLIC HEALTH RELEVANCE: The pathophysiology of schizophrenia may be reflected by abnormalities in neurochemical concentrations which reflect the activity of cellular transmission. Recently, we have developed new imaging techniques for precise measurements of experimentally-challenging brain metabolites in vivo. We propose, using these methods, to find biomarkers of molecular pathology in schizophrenia, to define the effect of antipsychotic treatment and to examine the correlation between metabolite levels and phenotypic expression of symptoms. This is an essential step toward establishing this new methodology and, ultimately, to better understanding the pathophysiology of the disorder. Eventually, data on altered levels of neurotransmitters and their metabolites, as long as they can be measured with precision, will provide important pieces of data that can be utilized for development of new treatments in schizophrenia.
描述(由申请人提供):趋同的证据线表明精神分裂症可能涉及谷氨酸神经传递的改变。虽然人类死后和动物模型研究对于实现这一理解至关重要,但对现有模型的任何明确测试都需要在人体内证明神经递质系统的病理。先前的研究表明,精神分裂症的谷氨酸能功能减退可能通过脑代谢物水平的改变来反映。在这个探索性的资助申请中,我们的目标是创造新的方法,利用质子磁共振波谱(MRS)在7 T下测量精神分裂症中谷氨酸相关的神经化学特征,利用信号增益和光谱分辨率增强的高场优势。我们最近开发了新的7 T MRS方法,可以精确测量几种具有实验挑战性的脑代谢物,包括谷氨酸、谷氨酰胺、GABA、甘氨酸、n -乙酰天冬氨酸谷氨酸、谷胱甘肽和肌醇,这些方法是通过对标准MRS序列的回声时间优化实现的。我们将测量这些脑代谢物的浓度,以及脑MRS中的其他主要信号(即n -乙酰天冬氨酸、肌酸和胆碱)、前扣带皮层(ACC)和背外侧前额叶皮层(DLPFC)中精神分裂症志愿者(SZ)和正常对照组(NC)的浓度。ACC和DLPFC是参与SZ最关键的大脑区域,因此本研究将与先前的一些研究建立一致的焦点。我们将招募40名SZ志愿者(20名服用抗精神病药物,SZ- on, 20名停药,SZ- off)和20名年龄匹配的对照组。每位患者将接受完整的检查,包括研究诊断(SCID)访谈、认知特征(matrix Battery)和症状评估(PANSS)。各组的MRS数据将进行差异分析,然后与患者特征相关联。我们将测试MRS组的差异是否与精神分裂症的特定表型有关。将对15名受试者(5名SZ-ON、5名SZ-OFF和5名对照)每隔2周进行复测-复测磁共振扫描,以评估磁共振数据的可重复性。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Changho Choi其他文献

Changho Choi的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Changho Choi', 18)}}的其他基金

Clinical development of cancer-specific MRS biomarkers in malignant gliomas
恶性胶质瘤癌症特异性 MRS 生物标志物的临床开发
  • 批准号:
    9336267
  • 财政年份:
    2014
  • 资助金额:
    $ 23.78万
  • 项目类别:
Clinical development of cancer-specific MRS biomarkers in malignant gliomas
恶性胶质瘤癌症特异性 MRS 生物标志物的临床开发
  • 批准号:
    8897306
  • 财政年份:
    2014
  • 资助金额:
    $ 23.78万
  • 项目类别:
Clinical development of cancer-specific MRS biomarkers in malignant gliomas
恶性胶质瘤癌症特异性 MRS 生物标志物的临床开发
  • 批准号:
    8674539
  • 财政年份:
    2014
  • 资助金额:
    $ 23.78万
  • 项目类别:
Clinical development of cancer-specific MRS biomarkers in malignant gliomas
恶性胶质瘤癌症特异性 MRS 生物标志物的临床开发
  • 批准号:
    9118131
  • 财政年份:
    2014
  • 资助金额:
    $ 23.78万
  • 项目类别:
In vivo detection of 2-hydroxyglutarate in gliomas by spectroscopic MRI
光谱 MRI 体内检测神经胶质瘤中的 2-羟基戊二酸
  • 批准号:
    8338812
  • 财政年份:
    2011
  • 资助金额:
    $ 23.78万
  • 项目类别:
In vivo detection of 2-hydroxyglutarate in gliomas by spectroscopic MRI
光谱 MRI 体内检测神经胶质瘤中的 2-羟基戊二酸
  • 批准号:
    8096384
  • 财政年份:
    2011
  • 资助金额:
    $ 23.78万
  • 项目类别:
7T MRS AND CEST IMAGING OF BRAIN TUMORS: BIOMARKERS OF THERAPEUTIC RESPONSE
脑肿瘤的 7T MRS 和 CEST 成像:治疗反应的生物标志物
  • 批准号:
    8363887
  • 财政年份:
    2011
  • 资助金额:
    $ 23.78万
  • 项目类别:
Novel High-field MRS Study of CNS Neurotransmitter Function in Schizophrenia
精神分裂症中枢神经递质功能的新型高场 MRS 研究
  • 批准号:
    8298136
  • 财政年份:
    2011
  • 资助金额:
    $ 23.78万
  • 项目类别:
7T MRS AND CEST IMAGING OF BRAIN TUMORS: BIOMARKERS OF THERAPEUTIC RESPONSE
脑肿瘤的 7T MRS 和 CEST 成像:治疗反应的生物标志物
  • 批准号:
    8171636
  • 财政年份:
    2010
  • 资助金额:
    $ 23.78万
  • 项目类别:
SPECTROSCOPY OF HUMAN BRAIN AT 7T
7T 下的人脑光谱
  • 批准号:
    7956949
  • 财政年份:
    2009
  • 资助金额:
    $ 23.78万
  • 项目类别:

相似国自然基金

靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
  • 批准号:
    JCZRQN202500010
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
  • 批准号:
    2025JJ70209
  • 批准年份:
    2025
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
  • 批准号:
  • 批准年份:
    2024
  • 资助金额:
    0 万元
  • 项目类别:
    面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
  • 批准号:
    2023JJ50274
  • 批准年份:
    2023
  • 资助金额:
    0.0 万元
  • 项目类别:
    省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
  • 批准号:
  • 批准年份:
    2022
  • 资助金额:
    33 万元
  • 项目类别:
    地区科学基金项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
  • 批准号:
    n/a
  • 批准年份:
    2022
  • 资助金额:
    10.0 万元
  • 项目类别:
    省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
  • 批准号:
    81973577
  • 批准年份:
    2019
  • 资助金额:
    55.0 万元
  • 项目类别:
    面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
  • 批准号:
    81602908
  • 批准年份:
    2016
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
  • 批准号:
    81501928
  • 批准年份:
    2015
  • 资助金额:
    18.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政​​策的情绪动态
  • 批准号:
    10108433
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
  • 批准号:
    MR/X032809/1
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
  • 批准号:
    MR/X034690/1
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
  • 批准号:
    2341426
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
  • 批准号:
    2341424
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
  • 批准号:
    2335955
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
  • 批准号:
    DP240103257
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
  • 批准号:
    DP240100408
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
  • 批准号:
    DP240100111
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
  • 批准号:
    502786
  • 财政年份:
    2024
  • 资助金额:
    $ 23.78万
  • 项目类别:
    Directed Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了