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COMPARISON OF A UNIFIED APPROACH AND THE TDT IN THE FRAMINGHAM HEART STUDY

COMPARISON OF A UNIFIED APPROACH AND THE TDT IN THE FRAMINGHAM HEART STUDY
Framingham 心脏研究中统一方法与 TDT 的比较
批准号:
7956501
负责人:
XIAOFENG ZHU
金额:
$0.48万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-08-01 至 2010-07-31

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项目成果

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中文摘要
翻译
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Population stratification is one of the major causes of spurious associations in association studies. A unified association approach (FamCC) based on principal component analysis can overcome the effect of population stratification, as well as make use of both family and unrelated samples combined to increase power. In this study, we compared FamCC and the transmission disequilibrium test (TDT) using data on hypertension, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the Framingham heart study. Our study indicated FamCC has reasonable type I error for both unrelated samples and family samples for all three traits. For the binary trait hypertension, we found results from FamCC were inconsistent with those from the TDT. We discuss the reasons for this inconsistency. After correcting for multiple tests, we did not detect any significant SNPs by either FamCC or the TDT. The results from FamCC and the TDT were most consistent for the quantitative trait DBP and least consistent for the binary trait hypertension.
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