A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
批准号:
8171724
负责人:
XIAOFENG ZHU
金额:
$0.99万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-08-01 至 2011-07-31
关键词:
ComplexComputer Retrieval of Information on Scientific Projects DatabaseDataDetectionFamilyFundingGeneticGenotypeGrantInstitutionJointsLinkage DisequilibriumMethodsModelingMolecular EpidemiologyPopulationPopulation ControlResearchResearch PersonnelResourcesSample SizeSamplingSourceStratificationTestingUnited States National Institutes of Healthbasecase controldesigngenome wide association studypreventtraittransmission processtrend
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
With the trend in molecular epidemiology towards both genome-wide association studies and complex modelling, the need for large sample sizes to detect small effects and to allow for the estimation of many parameters within a model continues to increase. Unfortunately, most methods of association analysis have been restricted to either a family-based or a case-control design, resulting in the lack of synthesis of data from multiple studies. Transmission disequilibrium-type methods for detecting linkage disequilibrium from family data were developed as an effective way of preventing the detection of association due to population stratification. Because these methods condition on parental genotype, however, they have precluded the joint analysis of family and case-control data, although methods for case-control data may not protect against population stratification and do not allow for familial correlations. We present here an extension of a family-based association analysis method for continuous traits that will simultaneously test for, and if necessary control for, population stratification. We further extend this method to analyse binary traits (and therefore family and case-control data together) and accurately to estimate genetic effects in the population, even when using an ascertained family sample. Finally, we present the power of this binary extension for both family-only and joint family and case-control data, and demonstrate the accuracy of the association parameter and variance components in an ascertained family sample.
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Statistical analysis of large genomic data sets
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批准号:10359127
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项目类别:
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资助金额:$38.95万
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财政年份:2020
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负责人:XIAOFENG ZHU
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依托单位:
Statistical analysis of large genomic data sets
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批准号:10561641
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项目类别:
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资助金额:$38.95万
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财政年份:2020
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负责人:XIAOFENG ZHU
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依托单位:
Statistical analysis of large genomic data sets
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批准号:10161804
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项目类别:
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资助金额:$38.95万
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财政年份:2020
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING OF QUANTITATIVE TRAIT LOCI FOR BMI IN AFRICAN-AMERICANS
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批准号:8171727
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
DETECTING RARE VARIANTS FOR COMPLEX TRAITS USING FAMILY AND UNRELATED DATA
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批准号:8171726
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
ASSOCIATION OF REGIONS WITH HYPERTENSION IN NIGERIAN FAMILIES
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批准号:8171728
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项目类别:
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资助金额:$0.49万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
A METHOD TO CORRECT FOR POPULATION STRUCTURE USING A SEGREGATION MODEL
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批准号:8171730
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
ASSESSING THE IMPACT OF GLOBAL VERSUS LOCAL ANCESTRY IN ASSOCIATION STUDIES
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批准号:8171729
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
DETECTING RARE VARIANTS FOR COMPLEX TRAITS USING FAMILY AND UNRELATED DATA
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批准号:7956494
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
GENOME-WIDE DISTRIBUTION OF ANCESTRY IN MEXICAN AMERICANS
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批准号:7956496
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
COMPARISON OF A UNIFIED APPROACH AND THE TDT IN THE FRAMINGHAM HEART STUDY
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批准号:7956501
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项目类别:
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资助金额:$0.48万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
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批准号:7956491
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
A METHOD TO CORRECT FOR POPULATION STRUCTURE USING A SEGREGATION MODEL
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批准号:7956500
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING AND ROLE OF POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES
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批准号:7956495
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项目类别:
-
资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ASSOCIATION OF REGIONS WITH HYPERTENSION IN NIGERIAN FAMILIES
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批准号:7956498
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项目类别:
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资助金额:$0.48万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING OF QUANTITATIVE TRAIT LOCI FOR BMI IN AFRICAN-AMERICANS
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批准号:7956497
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项目类别:
-
资助金额:$0.97万
-
财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ASSESSING THE IMPACT OF GLOBAL VERSUS LOCAL ANCESTRY IN ASSOCIATION STUDIES
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批准号:7956499
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项目类别:
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资助金额:$0.97万
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财政年份:2009
-
负责人:XIAOFENG ZHU
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依托单位:
A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
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批准号:7723464
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项目类别:
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资助金额:$0.91万
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财政年份:2008
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING AND POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES
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批准号:7723465
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项目类别:
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资助金额:$0.45万
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财政年份:2008
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING IDENTIFIES ASSOCIATION OF THE VNN1 GENE WITH HYPERTENSION
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批准号:7723463
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项目类别:
-
资助金额:$0.91万
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财政年份:2008
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负责人:XIAOFENG ZHU
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依托单位: