DETECTING RARE VARIANTS FOR COMPLEX TRAITS USING FAMILY AND UNRELATED DATA
DETECTING RARE VARIANTS FOR COMPLEX TRAITS USING FAMILY AND UNRELATED DATA
批准号:
8171726
负责人:
XIAOFENG ZHU
金额:
$0.99万
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-08-01 至 2011-07-31
关键词:
AccountingCandidate Disease GeneComplexComputer Retrieval of Information on Scientific Projects DatabaseCoronary ArteriosclerosisDNA ResequencingDataDiseaseFamilyFundingGenesGrantHaplotypesHypertensionInstitutionMethodsReportingResearchResearch PersonnelResourcesRiskSamplingSourceTestingTrustUnited States National Institutes of HealthVariantbasecase controldesigngenetic variantgenome wide association studygenome-wideinteresttrait
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Large genome-wide association studies (GWAS) have been performed to detect common genetic variants involved in common diseases, but most of the variants found this way account for only a small portion of the trait variance. Furthermore, candidate gene-based resequencing suggests that many rare genetic variants contribute to the trait variance of common diseases. Here we propose two designs, sibpair and unrelated-case designs, to detect rare genetic variants in either a candidate gene-based or genome-wide association analysis. First we show that we can detect and classify together rare risk haplotypes using a relatively small sample with either of these designs, and then have increased power to test association in a larger case-control sample. This method can also be applied to resequencing data. Next we apply the method to the Wellcome Trust Case Control Consortium (WTCCC) coronary artery disease (CAD) and hypertension (HT) data, the latter being the only trait for which no genome-wide association evidence was reported in the original WTCCC study, and identify one interesting gene associated with HT and four associated with CAD at a genome-wide significance level of 5%. These results suggest that searching for rare genetic variants is feasible and can be fruitful in current GWAS, candidate gene studies or resequencing studies.
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Statistical analysis of large genomic data sets
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批准号:10359127
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项目类别:
-
资助金额:$38.95万
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财政年份:2020
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负责人:XIAOFENG ZHU
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依托单位:
Statistical analysis of large genomic data sets
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批准号:10561641
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项目类别:
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资助金额:$38.95万
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财政年份:2020
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负责人:XIAOFENG ZHU
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依托单位:
Statistical analysis of large genomic data sets
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批准号:10161804
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项目类别:
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资助金额:$38.95万
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财政年份:2020
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING OF QUANTITATIVE TRAIT LOCI FOR BMI IN AFRICAN-AMERICANS
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批准号:8171727
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
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批准号:8171724
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
ASSOCIATION OF REGIONS WITH HYPERTENSION IN NIGERIAN FAMILIES
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批准号:8171728
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项目类别:
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资助金额:$0.49万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
A METHOD TO CORRECT FOR POPULATION STRUCTURE USING A SEGREGATION MODEL
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批准号:8171730
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项目类别:
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资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
ASSESSING THE IMPACT OF GLOBAL VERSUS LOCAL ANCESTRY IN ASSOCIATION STUDIES
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批准号:8171729
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项目类别:
-
资助金额:$0.99万
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财政年份:2010
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负责人:XIAOFENG ZHU
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依托单位:
DETECTING RARE VARIANTS FOR COMPLEX TRAITS USING FAMILY AND UNRELATED DATA
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批准号:7956494
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
GENOME-WIDE DISTRIBUTION OF ANCESTRY IN MEXICAN AMERICANS
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批准号:7956496
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
COMPARISON OF A UNIFIED APPROACH AND THE TDT IN THE FRAMINGHAM HEART STUDY
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批准号:7956501
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项目类别:
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资助金额:$0.48万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
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批准号:7956491
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项目类别:
-
资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
A METHOD TO CORRECT FOR POPULATION STRUCTURE USING A SEGREGATION MODEL
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批准号:7956500
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项目类别:
-
资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING AND ROLE OF POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES
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批准号:7956495
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项目类别:
-
资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ASSOCIATION OF REGIONS WITH HYPERTENSION IN NIGERIAN FAMILIES
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批准号:7956498
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项目类别:
-
资助金额:$0.48万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING OF QUANTITATIVE TRAIT LOCI FOR BMI IN AFRICAN-AMERICANS
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批准号:7956497
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项目类别:
-
资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
ASSESSING THE IMPACT OF GLOBAL VERSUS LOCAL ANCESTRY IN ASSOCIATION STUDIES
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批准号:7956499
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项目类别:
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资助金额:$0.97万
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财政年份:2009
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负责人:XIAOFENG ZHU
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依托单位:
A UNIFIED ASSOCIATION ANALYSIS APPROACH FOR FAMILY AND UNRELATED SAMPLES
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批准号:7723464
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项目类别:
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资助金额:$0.91万
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财政年份:2008
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING AND POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES
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批准号:7723465
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项目类别:
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资助金额:$0.45万
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财政年份:2008
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负责人:XIAOFENG ZHU
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依托单位:
ADMIXTURE MAPPING IDENTIFIES ASSOCIATION OF THE VNN1 GENE WITH HYPERTENSION
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批准号:7723463
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项目类别:
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资助金额:$0.91万
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财政年份:2008
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负责人:XIAOFENG ZHU
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依托单位:
海外基金