RAPID TRANSLATION OF NOVEL CYANIDE TREATMENT DRUGS TO CLIN PRACTICE USING DOS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 评估和优化1）可宾酰胺、2）巯基嘌呤二噻烷（MP-二噻烷）和3）可宾酰胺和MP-二噻烷联合治疗与当前可用治疗和对照相比逆转家兔模型中氰化物毒性的能力，以及应用新型非侵入性技术（DOS）评估这些药物的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To assess and optimize the capabilities of 1) cobinamide, 2) Mercaptopurine Dithiane (Mp-Dithiane), and 3) combination therapies of cobinamide and Mp-Dithiane to reverse cyanide toxicity in a rabbit model compared to currently available treatments and controls, and application of novel non-invasive technology (DOS) for assessment of effects of these drugs.