RAPID TRANSLATION OF NOVEL CYANIDE TREATMENT DRUGS TO CLIN PRACTICE USING DOS
RAPID TRANSLATION OF NOVEL CYANIDE TREATMENT DRUGS TO CLIN PRACTICE USING DOS
批准号:
7956527
负责人:
MATTHEW BRENNER
金额:
$0.27万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-08-01 至 2010-07-31
关键词:
6-MercaptopurineCombined Modality TherapyComputer Retrieval of Information on Scientific Projects DatabaseCyanidesFluorescenceFundingGrantInstitutionLaboratoriesModelingOryctolagus cuniculusPharmaceutical PreparationsResearchResearch PersonnelResourcesSourceTechnologyToxic effectTranslationsUnited States National Institutes of Healthcobinamidedithianenovel
中文摘要
这个子项目是许多利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
评估和优化1)可宾酰胺、2)巯基嘌呤二噻烷(MP-二噻烷)和3)可宾酰胺和MP-二噻烷联合治疗与当前可用治疗和对照相比逆转家兔模型中氰化物毒性的能力,以及应用新型非侵入性技术(DOS)评估这些药物的作用。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
To assess and optimize the capabilities of 1) cobinamide, 2) Mercaptopurine Dithiane (Mp-Dithiane), and 3) combination therapies of cobinamide and Mp-Dithiane to reverse cyanide toxicity in a rabbit model compared to currently available treatments and controls, and application of novel non-invasive technology (DOS) for assessment of effects of these drugs.
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批准号:7658821
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项目类别:
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资助金额:$26.08万
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财政年份:2007
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负责人:MATTHEW BRENNER
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依托单位:
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批准号:7880254
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项目类别:
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资助金额:$26.08万
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财政年份:2007
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负责人:MATTHEW BRENNER
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依托单位:
High Resolution Optical Coherence Tomography for Early Airway Cancer Detection
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批准号:8099626
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项目类别:
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资助金额:$25.3万
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财政年份:2007
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负责人:MATTHEW BRENNER
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依托单位:
High Resolution Optical Coherence Tomography for Early Airway Cancer Detection
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批准号:7323726
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项目类别:
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资助金额:$26.08万
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财政年份:2007
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负责人:MATTHEW BRENNER
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依托单位:
High Resolution Optical Coherence Tomography for Early Airway Cancer Detection
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批准号:7482339
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项目类别:
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资助金额:$26.08万
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财政年份:2007
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负责人:MATTHEW BRENNER
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依托单位:
NON INVASIVE OPTICAL ASSESSMENT OF TRAUMA
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批准号:7365596
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项目类别:
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资助金额:$2.65万
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财政年份:2006
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负责人:MATTHEW BRENNER
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依托单位:
NON INVASIVE OPTICAL ASSESSMENT OF TRAUMA
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批准号:7180292
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项目类别:
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资助金额:$2.29万
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财政年份:2005
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负责人:MATTHEW BRENNER
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依托单位:
NON INVASIVE OPTICAL ASSESSMENT OF TRAUMA
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批准号:6976167
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项目类别:
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资助金额:$3.57万
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财政年份:2004
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负责人:MATTHEW BRENNER
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依托单位:
Rapid translation of novel cyanide treatment drugs to clinical practice using DOS
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批准号:7573786
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项目类别:
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资助金额:$49.77万
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财政年份:--
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负责人:MATTHEW BRENNER
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依托单位:
Photonics Monitoring and Modeling Core
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批准号:9145048
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项目类别:
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资助金额:$69.13万
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财政年份:--
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负责人:MATTHEW BRENNER
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依托单位:
Rapid translation of novel cyanide treatment drugs to clinical practice using DOS
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批准号:8130860
-
项目类别:
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资助金额:$39.91万
-
财政年份:--
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负责人:MATTHEW BRENNER
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依托单位:
Rapid translation of novel cyanide treatment drugs to clinical practice using DOS
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批准号:7918866
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项目类别:
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资助金额:$46.32万
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财政年份:--
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负责人:MATTHEW BRENNER
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依托单位:
海外基金