High Resolution Optical Coherence Tomography for Early Airway Cancer Detection

用于早期气道癌症检测的高分辨率光学相干断层扫描

基本信息

批准号：
7658821
负责人：
MATTHEW BRENNER
金额：
$ 26.08万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-13 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7658821
关键词：
3-Dimensional Activities of Daily Living Adult Advanced Development Affect American Animal Experimentation Animal Model Animals Applications Grants Benign Biomedical Engineering Biopsy Blinded Bronchogenic Carcinoma Bronchoscopy Caliber California Cancer Center Cancer Detection Cancer Diagnostics Cancer Etiology Cancer Patient Categories Centers for Disease Control and Prevention (U.S.)Cessation of life Chest Clinical Clinical Research Clinical Trials Cytology Detection Development Diagnosis Diagnostic Diagnostic Procedure Diagnostic Specificity Differential Diagnosis Early Diagnosis Effectiveness Endoscopy Engineering Equipment Evaluation Excision Exclusion Family history of Feasibility Studies Fluorescence Future Goals Gold Grant Granulation Tissue Granuloma Histologic Histology Human Image Imagery Imaging technology Incidence Individual Institutes Institution Laboratories Lasers Life Lobectomy Lung Lung nodule Malignant - descriptor Malignant Neoplasms Malignant Pleural Effusion Malignant neoplasm of lung Maps Medical center Metaplasia Methods Microscopic Modality Needles Neoplasms Nodule Operative Surgical Procedures Optical Coherence Tomography Optics Pathologic Patients Penetration Peripheral Peritoneal Pleural Pleural Neoplasms Pneumonectomy Procedures Pulmonary Emphysema Pulmonology Research Research Design Research Proposals Resolution Risk Factors Scanning Screening for cancer Screening procedure Sensitivity and Specificity Site Smoke Smoker Specimen Speed Staging Surface Techniques Technology Therapeutic Thoracentesis Thoracoscopy Time Tissues Translating United States National Institutes of Health Universities Validation X-Ray Computed Tomography analytical method base cancer diagnosis design design and construction effusion flexibility high risk imaging modality improved in vivo minimally invasive novel practical application pre-clinical preclinical study prototype response technology development tumor ultra high resolution

项目摘要

DESCRIPTION (PROVIDED BY APPLICANT): Background: Lung cancer is the leading cause of cancer death in the US. Development of novel high resolution endoscopy is essential for more accurate diagnosis, staging, and treatment of endobronchial malignancy. Recent advances in rapid acquisition high-resolution flexible fiberoptic and rigid probe optical coherence tomography (OCT) offer the potential for endoscopic real-time near histologic level optical maging to substantially advance detection, diagnostics, and treatment approaches to airway cancer. Adaptation of endoscopic OCT to airway diagnostics and therapeutics will be a major advance that requires: 1) development of 2 and 3 dimensional MEMS endoscopic probes, 2) improved acquisition times, resolution, and contrast, and 3) translational pre-clinical studies for hardware and technique optimization, and 4) clinical patient studies for demonstration of capabilities and validation of OCT for airway cancer detection. This grant proposal focuses on advancing development and clinical investigation of real-time high- resolution endoscopic OCT technology directed at specific lung cancer applications where the need for flexible and rigid high-resolution optical endoscopy is well-defined: 1) evaluation and assessment of endobronchial cancer margins, and 2) assessment of improved endobronchial cancer detection feasibility. Objectives and Aims: The overall objectives of this research proposal are to develop high resolution 3- dimensional functional OCT (F-OCT) endoscopy and evaluate its capabilities for airway early cancer detection and assessment in patients. The Specific Aims are: 1) Further the development of i) small diameter (1mm) fiberoptic, MEMS, and ii) endoscopic 3-D grid OCT probes for rigid bronchoscopy. The rigid probes will also be usable for thoracoscopy and other endoscopy applications). 2) Translate F-OCT technology to diagnosis of lung cancer and to determine OCT sensitivity and specificity capabilities for airway cancer diagnosis. 3) Combine OCT with fluorescence endoscopic technologies in clinical studies to detect bronchoscopic airway tumor with high diagnostic specificity compared to histology Study Design: Flexible fiberoptic and rigid endoscopic probe prototypes for detecting airway malignancy margins and early airway cancers will be optimized for bronchoscopic and endoscopic imaging applications in pre clinical studies, then in clinical studies to detect cancer in patients with suspected airway malignancy. Relevance: This project will develop fully functional real-time near microscopic resolution airway imaging methods and demonstrate their effectiveness in improving early airway cancer diagnosis in patients. This extension of novel engineering imaging ideas to the treatment should also enable a range of other pulmonary and non-pulmonary scope imaging applications

描述（由申请人提供）：背景：肺癌是美国癌症死亡的主要原因。新型高分辨率内窥镜检查的发展对于更准确的诊断，分期和支撑型恶性肿瘤治疗至关重要。快速获取高分辨率的柔性光纤和刚性探针光学相干断层扫描（OCT）的最新进展为内窥镜实时接近组织学水平光学涂抹提供了潜在的，可以实质性地进行预测，诊断和治疗方法。 Adaptation of endoscopic OCT to airway diagnostics and therapeutics will be a major advance that requires: 1) development of 2 and 3 dimensional MEMS endoscopic probes, 2) improved acquisition times, resolution, and contrast, and 3) translational pre-clinical studies for hardware and technique optimization, and 4) clinical patient studies for demonstration of capabilities and validation of OCT for airway cancer detection.该赠款提案的重点是推进针对特定肺癌应用的实时高分辨率内窥镜OCT技术的开发和临床研究，在这些技术中，对灵活且刚性高分辨率的光学内窥镜的需求有明确的定义：1）评估和评估内物理癌的评估，以及2）评估提高的内向癌症的评估。目标和目的：该研究建议的总体目标是开发高分辨率3-维功能性OCT（F-OCT）内窥镜检查，并评估其在患者的气道早期癌症检测和评估的能力。具体目的是：1）进一步的发育i）小直径（1mm）纤维，mem和ii）内镜3-D网格OCT探针进行刚性支气管镜检查。刚性探针也将用于胸腔镜检查和其他内窥镜应用）。 2）将F-OCT技术转化为肺癌的诊断，并确定OCT的灵敏度和气道癌诊断的特异性能力。 3) Combine OCT with fluorescence endoscopic technologies in clinical studies to detect bronchoscopic airway tumor with high diagnostic specificity compared to histology Study Design: Flexible fiberoptic and rigid endoscopic probe prototypes for detecting airway malignancy margins and early airway cancers will be optimized for bronchoscopic and endoscopic imaging applications in pre clinical studies, then in clinical studies to可疑气道恶性肿瘤患者的癌症。相关性：该项目将在微观分辨率的呼吸道成像方法附近开发出功能齐全的实时功能，并证明它们在改善患者早期气道癌症诊断方面的有效性。新颖的工程成像思想延伸到治疗也应促进一系列其他肺部和非肺部范围成像应用