Photonics Monitoring and Modeling Core

光子学监控和建模核心

• 批准号: 9145048
• 负责人: MATTHEW BRENNER
• 金额: $ 69.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9145048
• 关键词: Accidents; Acute; Animal Model; Animal Testing; Animals; Antidotes; Breathing; California; Cessation of life; Chemical Agents; Chemical Exposure; Chemicals; Chronic; Colorado; Core Facility; Cyanides; Cytochromes; Development; Diagnostic; Diffuse; Family suidae; Fiber Optics; Gases; Human; Image; In Vitro; Injury; Institutes; Investigation; Laboratories; Lasers; Metabolic; Modeling; Monitor; Mustard; Near-Infrared Spectroscopy; Operating Rooms; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Oxidases; Oxidation-Reduction; Pain; Rattus; Research; Research Personnel; Resolution; Role; Source; Spectrum Analysis; Structure; Sulfhydryl Compounds; Technology; Terrorism; Testing; Three-Dimensional Imaging; Time; Tissues; Treatment Effectiveness; Universities; Vesicants; abstracting; animal facility; base; drug development; in vivo; injured airway; metabolic poison; methyl isocyanate; microsensor; novel diagnostics; photonics; sensor; tissue oxygenation

Photonics Monitoring and Modeling Core Abstract The Photonics Monitoring and Modeling Core (PMMC) consists of three core photonics based novel diagnostic technologies and a highly monitored mid-size animal model (rabbit) testing facility based at the University of California, Irvine, Beckman Laser Institute that support investigations at UC Irvine, UC San Diego, and the University of Colorado. The Core will provide all investigators with photonics technologies across all animal models to enable accurate, precise, quantitative and semi-quantitative, high-resolution imaging and monitoring capabilities in-vivo. The Core will provide technology and support at the U. C. Irvine rabbit testing facility, as well as in laboratories at the U. of Colorado for inhalation injury small animal studies (Drs. White, Veress), and Large Animal Core projects (Dr. Bebarta), supporting projects 1 (methyl isocyanate), 2 (mustard), 3 (methylmercaptan), and 4 (cyanide). The Core photonics based technologies include: 1) swept-source optical coherence tomography for real-time, fiber optic, micron resolution, 3-D imaging of airways for assessment of acute and chronic airway injury for chronic mustard exposure and methyl isocyanate exposures in rats and pigs (projects 1, 2 and the Large Animal Core), 2) diffuse optical spectroscopy and continuous wave near infrared spectroscopy for assessment of effects of the metabolic poisons, cyanide and methylmercaptan, and monitoring of tissue oxygenation and Cytochrome C oxidase redox states in the rabbit and swine models (projects 3 and 4), and 3) real-time micro-sensors for continuous tissue lactate monitoring in animals with metabolic poison exposures (projects 3, 4, and the Large Animal Core). The core will also provide state-of-the-art rabbit testing facility and established core models for metabolic agent antidote development supporting projects 3 and 4. Advanced technology capabilities will be extended to the U. of Colorado as part of the PMMC deliverables, and will function there in addition to their ongoing availability in the photonics testing facility and animal operating rooms at UC Irvine Beckman Laser Institute. As shown in our prior chemical defense research, these core technologies enable more accurate, precise, and noninvasive determination of injury and treatment effectiveness, dramatically accelerating antidote development and reducing animal numbers required for definitive results. Thus, the Core is integrally involved in Projects 1, 2, 3, 4, the Large Animal Core, and in the overarching structure of this “pipeline from in-vitro, to small animal, to moderate and large animal” accelerated chemical agent antidote drug development proposal.

光子学监测和建模核心 抽象的 光子学监测和建模核心（PMMC）由三个核心光子学组成 基于新型的诊断技术和高度监测的中型动物模型（兔子） 位于加州大学欧文分校的贝克曼激光研究所的测试设施 加州大学欧文分校，加州大学圣地亚哥分校和科罗拉多大学的支持调查。核心 将向所有研究人员提供所有动物模型的光子技术，以启用 准确，精确，定量和半定量，高分辨率成像和 监视功能在体内。核心将在U.C. 尔湾兔测试设施以及科罗拉多州美国实验室的事故 损伤小动物研究（怀特博士，veress）和大型动物核心项目（博士 Bebarta），支持项目1（异氰酸甲酯），2（芥末），3（甲基汞）和 4（氰化物）。基于核心光子学的技术包括：1）扫描源光学 实时的相干断层扫描，光纤，微分分辨率，3-D气道成像 用于评估慢性芥末和甲基的急性和慢性气道损伤 大鼠和猪的异氰酸盐暴露（项目1、2和大动物核心），2）弥漫 光谱和连续波接近感染光谱，以评估 代谢毒物，氰化物和甲基汞的影响以及组织的监测 兔和猪模型中的氧合和细胞色素C氧化酶氧化还原态 （项目3和4）和3）连续组织监测的实时微传感器 在具有代谢毒物暴露的动物中（项目3、4和大动物核心）。 核心还将提供最先进的兔子测试设施，并为 代谢剂解毒剂开发支持项目3和4。先进技术 作为PMMC可交付成果的一部分，功能将扩展到科罗拉多州，并将 除了它们在光子学测试设施中的持续可用性外，还有功能 UC Irvine Beckman Laser Institute的动物手术室。如我们先前的 化学防御研究，这些核心技术可以更准确，精确和 无创确定伤害和治疗效果，急剧加速 解毒剂的发展和减少确定结果所需的动物数量。那， 核心与项目1、2、3、4，大动物核心以及 从维特罗到小动物，再到现代和大型的管道的总体结构 动物”加速化学剂解毒药物开发建议。