ASSESSMENT OF REPRODUCIBILITY OF 3HE MRI OXYGEN MEASUREMENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 肺氧分压(PO2)和氧耗率(Odr)是两个重要的指标 肺功能参数。超极化(HP)~3He T_1对局域氧的依赖关系 浓度为高分辨率绘制pO2区域分布图提供了基础 以及肺部的药物残留。尽管氧敏HP 3He磁共振成像技术已应用于 在人类受试者和几个动物物种中，重复性研究很少在 文学。这项工作提供了一个猪模型的初步重复性研究。在这项研究中， 重要的扫描参数(如测量定时和翻转角度)经过优化，以 将噪声引起的测量不确定度降至最低。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulmonary partial pressure of oxygen (pO2) and oxygen depletion rate (ODR) are two important functional parameters of lung. The dependence of hyperpolarized (HP) 3He T1 on local oxygen concentration provides the basis for high-resolution mapping of the regional distributions of pO2 and ODR in the lung. Although the oxygen-sensitive HP 3He MRI technique has been applied in human subjects and several animal species, reproducibility studies are rarely reported in the literature. This work presents a preliminary reproducibility study on a pig model. In this study, important scan parameters, such as measurement timing and flip angle, are optimized to minimize the noise-induced measurement uncertainty.