ASSESSMENT OF REPRODUCIBILITY OF 3HE MRI OXYGEN MEASUREMENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 肺氧分压（pO 2）和氧耗率（ODR）是两个重要的 肺功能参数。超极化（HP）~ 3 He T_1对局部氧的依赖性 浓度为pO 2区域分布的高分辨率绘图提供了基础 和ODR虽然氧敏HP ~ 3 He MRI技术已应用于 人类受试者和几种动物物种，重现性研究很少报告， 文学本工作提出了一个初步的重复性研究的猪模型。在本研究中， 诸如测量定时和翻转角等重要扫描参数被优化， 最小化噪声引起的测量不确定性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Pulmonary partial pressure of oxygen (pO2) and oxygen depletion rate (ODR) are two important functional parameters of lung. The dependence of hyperpolarized (HP) 3He T1 on local oxygen concentration provides the basis for high-resolution mapping of the regional distributions of pO2 and ODR in the lung. Although the oxygen-sensitive HP 3He MRI technique has been applied in human subjects and several animal species, reproducibility studies are rarely reported in the literature. This work presents a preliminary reproducibility study on a pig model. In this study, important scan parameters, such as measurement timing and flip angle, are optimized to minimize the noise-induced measurement uncertainty.