SIMULTANEOUS MEASUREMENTS USING HYPERPOLARIZED 3HE MRI

使用超极化 3HE MRI 进行同步测量

• 批准号: 7600807
• 负责人: JINGHUA YU
• 金额: $ 3.3万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7600807
• 关键词: Alveolar; Computer Retrieval of Information on Scientific Projects Database; Disease Progression; Funding; Gases; Goals; Grant; Institution; Invasive; Lung; Lung diseases; Magnetic Resonance Imaging; Maps; Measurement; Oxygen; Radioactive; Rate; Research; Research Personnel; Resources; Respiratory physiology; Source; Structure; Techniques; United States National Institutes of Health; improved; in vivo; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to obtain regional maps of the important functional lung parameters using nuclear magnetic resonance imaging of hyperpolaizd 3He gas. This project will refine and characterize a safe, sensitive, regional, quantitative, non-invasive and non-radioactive MR technique that offers the newfound ability to detect early changes in lung function and structure associated with pulmonary diseases, to quantitatively follow the progression of disease and to immediately ascertain response to therapy. The specific aim for this project is to improve the measurement technique for in-vivo measurements of the alveolar oxygen concentration and the oxygen depletion rate (ODR).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本项目的总体目标是使用超极化3 He气体的核磁共振成像获得重要功能性肺参数的区域图。 该项目将完善和表征一种安全、敏感、区域、定量、非侵入性和非放射性的MR技术，该技术提供了新发现的检测与肺部疾病相关的肺功能和结构早期变化的能力，定量跟踪疾病进展并立即确定对治疗的反应。 该项目的具体目标是改进用于肺泡氧浓度和氧消耗率（ODR）的体内测量的测量技术。