SIMULTANEOUS MEASUREMENTS USING HYPERPOLARIZED 3HE MRI

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to obtain regional maps of the important functional lung parameters using nuclear magnetic resonance imaging of hyperpolaizd 3He gas. This project will refine and characterize a safe, sensitive, regional, quantitative, non-invasive and non-radioactive MR technique that offers the newfound ability to detect early changes in lung function and structure associated with pulmonary diseases, to quantitatively follow the progression of disease and to immediately ascertain response to therapy. The specific aim for this project is to improve the measurement technique for in-vivo measurements of the alveolar oxygen concentration and the oxygen depletion rate (ODR).