SIMULTANEOUS MEASUREMENTS OF ADC AND PO2

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In recent years, hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI) has been used extensively for quantitative assessments of pulmonary structural and functional parameters. Alveolar size airway morphology at the smallest spatial scales can be elucidated using HP 3He MR apparent diffusion coefficient (ADC) imaging. The pulmonary oxygen measurement, which is an example of functional imaging, yields regional alveolar oxygen tension (pO2) and depletion rate (ODR). In our previous work, we proposed a multiple-regression-based single acquisition technique for simultaneously measuring ADC, pO2 and ODR. In this project, we expand this technique and present a new acquisition scheme which additionally includes a characterization of regional air exchange efficiency, termed fractional ventilation (r).