FUNCTION PROFILE OF UBIQUITIN RECEPTOR RPN13

泛素受体 RPN13 的功能概况

• 批准号: 7954676
• 负责人: Kylie J. Walters
• 金额: $ 0.49万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954676
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Degradation Pathway; Deubiquitinating Enzyme; Funding; Grant; Institution; Play; Research; Research Personnel; Resources; Role; Source; Techniques; Ubiquitin; United States National Institutes of Health; multicatalytic endopeptidase complex; protein degradation; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Rpn13 is a proteasome component and newly identified as a ubiquitin receptor. Rpn13 is also the proteasomal receptor for a deubiquitinating enzyme Uch37. These make Rpn13 playing important roles in protein degradation pathway. The function profile of Rpn13 is expected to be elucidated by using modern NMR techniques.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 rpn 13是一种蛋白酶体成分，是一种新发现的泛素受体。Rpn 13也是去泛素化酶Uch 37的蛋白酶体受体。这使得Rpn 13在蛋白质降解途径中发挥重要作用。Rpn 13的功能概况有望通过使用现代NMR技术来阐明。