IDENTIFICATION OF SMALL MOLECULES TO TARGET PROKARYOTIC CYTOSKELETAL ELEMENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 小分子是研究细菌和真核生物细胞骨架的重要工具，因为它们可以在体内快速脱纤维或稳定纤维。然而，只有有限数量的靶向细菌细胞骨架的小分子已被确定。本项目将在C.克雷森塔斯一旦确定，小分子将在实验室合成，以进一步表征。NMR将用于验证这些小分子的纯度和结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Small molecues represent an important tool for studying both bacterial and eukaryotic cytoskeletons because they make it possible to rapidly depolymerize or stabilize a filament in vivo. However, only a limited number of small molecules that target the bacterial cytoskeleton have been identified. This project will identify new small molecule inhibitors of bacterial cytoskeletal elements in C. Crecentus. Once identified, the small molecules will be synthesized in the laboratory for further characterization. NMR will be used to veryify the purity and structure of these small molecules.