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HIGH-RESOLUTION REFINEMENT OF PROTEIN STRUCTURE FRO NMR CHEMICAL SHIFTS

HIGH-RESOLUTION REFINEMENT OF PROTEIN STRUCTURE FRO NMR CHEMICAL SHIFTS
利用 NMR 化学位移对蛋白质结构进行高分辨率精修
批准号：
7957350
负责人：
CHARLES L BROOKS
金额：
$5.94万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-09-01 至 2010-08-31
来源：
https://reporter.nih.gov/project-details/7957350
关键词：
AreaArenavirusChemicalsComputer Retrieval of Information on Scientific Projects DatabaseDataFundingGrantInstitutionInvestigationResearchResearch PersonnelResolutionResourcesSourceStructureUnited States National Institutes of HealthWorkbasemolecular dynamicsmulti-scale modelingplasma protein Zprotein structurestructural biologytool

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中文摘要
翻译
该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 在一个新的研究领域，我们正在扩展我们早期的工作，结合副本交换分子动力学与原子水平结构的基础上NMR数据的细化。在目前的努力中，我们已经单独利用化学位移数据作为沙粒病毒Z蛋白的结构系综细化的约束。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In a new area of investigation, we are extending our earlier work that combined replica exchange molecular dynamics with the refinement of atomic level structures based on NMR data. In the current efforts, we have utilized chemical shift data alone as a constraint on the refinement of a structural ensemble of the arenavirus Z-protein.
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