CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES
CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES
批准号:
7954338
负责人:
HARRY F NOLLER
金额:
$1.14万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-03-01 至 2010-02-28
中文摘要
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得主要资金,
因此可以在其他CRISP条目中表示。列出的机构是
研究中心,而研究中心不一定是研究者所在的机构。
我们对70 S核糖体结构研究的重点是获得与核糖体翻译过程中不同状态相对应的不同功能复合物的高分辨率结构。含有mRNA、tRNA、翻译因子和其他配体的各种组合的核糖体复合物正在被构建和结晶用于结构分析。我们的最终目标是将产生的结构组装成一个高分辨率的“电影”,当它发生在核糖体上时,它将提供翻译的描述。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
The focus of our structural studies on the 70S ribosome is to obtain high resolution structures of different functional complexes corresponding to different states of the ribosome during translation. Ribosome complexes containing various combinations of mRNA, tRNAs, translational factors and other ligands are being constructed and crystallized for structural analysis. Our ultimate goal is to assemble the resulting structures into a high-resolution 'movie' that will provide a description of translation as it occurs on the ribosome.
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批准号:10405474
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项目类别:
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资助金额:$76.6万
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财政年份:2016
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负责人:HARRY F NOLLER
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依托单位:
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项目类别:
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资助金额:$77.23万
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财政年份:2016
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负责人:HARRY F NOLLER
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批准号:10597704
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项目类别:
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资助金额:$76.6万
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财政年份:2016
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批准号:9252498
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项目类别:
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资助金额:$77.23万
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财政年份:2016
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负责人:HARRY F NOLLER
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CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES
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批准号:8362118
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项目类别:
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资助金额:$4.88万
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财政年份:2011
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负责人:HARRY F NOLLER
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依托单位:
MACCHESS PROGRAM FOR PRESSURE CRYOCOOLING AND RELATED PROCEDURES
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批准号:8171530
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项目类别:
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资助金额:$1.37万
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财政年份:2010
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES
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批准号:8170025
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项目类别:
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资助金额:$2.14万
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财政年份:2010
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负责人:HARRY F NOLLER
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依托单位:
A High-Throughput Crystallization Screening System for the UCSC Macromolecular X-
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批准号:7390440
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项目类别:
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资助金额:$25.01万
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财政年份:2008
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES
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批准号:7721990
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项目类别:
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资助金额:$1.97万
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财政年份:2008
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES
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批准号:7598245
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项目类别:
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资助金额:$0.06万
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财政年份:2007
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURE OF THE RIBOSOME
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批准号:7598065
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项目类别:
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资助金额:$0.38万
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财政年份:2007
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURE OF THE RIBOSOME
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批准号:7370562
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项目类别:
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资助金额:$0.09万
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财政年份:2006
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负责人:HARRY F NOLLER
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依托单位:
USING FRET TO STUDY RIBOSOME DYNAMICS
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批准号:7181213
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项目类别:
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资助金额:$2.13万
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财政年份:2005
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURE OF THE RIBOSOME
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批准号:7180485
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项目类别:
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资助金额:$0.24万
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财政年份:2005
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负责人:HARRY F NOLLER
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依托单位:
USING FRET TO STUDY RIBOSOME DYNAMICS
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批准号:6977628
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项目类别:
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资助金额:$0.5万
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财政年份:2004
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负责人:HARRY F NOLLER
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依托单位:
X-Ray Crystallography Imaging Plate Detector
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批准号:6440166
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项目类别:
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资助金额:$26.4万
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财政年份:2002
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负责人:HARRY F NOLLER
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依托单位:
CRYSTAL STRUCTURE OF THE RIBOSOME
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批准号:6181422
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项目类别:
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资助金额:$41.45万
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财政年份:1999
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负责人:HARRY F NOLLER
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依托单位:
Crystal Structure of the Ribosome
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批准号:6777320
-
项目类别:
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资助金额:$56.99万
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财政年份:1999
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负责人:HARRY F NOLLER
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依托单位:
Crystal Structure of the Ribosome
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批准号:6871322
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项目类别:
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资助金额:$47.94万
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财政年份:1999
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负责人:HARRY F NOLLER
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依托单位: