CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 我们对70 S核糖体结构研究的重点是获得与核糖体翻译过程中不同状态相对应的不同功能复合物的高分辨率结构。含有mRNA、tRNA、翻译因子和其他配体的各种组合的核糖体复合物正在被构建和结晶用于结构分析。我们的最终目标是将产生的结构组装成一个高分辨率的“电影”，当它发生在核糖体上时，它将提供翻译的描述。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of our structural studies on the 70S ribosome is to obtain high resolution structures of different functional complexes corresponding to different states of the ribosome during translation. Ribosome complexes containing various combinations of mRNA, tRNAs, translational factors and other ligands are being constructed and crystallized for structural analysis. Our ultimate goal is to assemble the resulting structures into a high-resolution 'movie' that will provide a description of translation as it occurs on the ribosome.