CRYSTAL STRUCTURES OF RIBOSOME COMPLEXES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们对70年代核糖体结构研究的重点是获得与核糖体在翻译过程中的不同状态相对应的不同功能复合体的高分辨结构。核糖体复合体包括各种不同的mRNA、tRNAs、翻译因子和其他配体的组合，正在构建和结晶以进行结构分析。我们的最终目标是将产生的结构组装成一部高分辨率的电影，提供对核糖体上发生的翻译的描述。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The focus of our structural studies on the 70S ribosome is to obtain high resolution structures of different functional complexes corresponding to different states of the ribosome during translation. Ribosome complexes containing various combinations of mRNA, tRNAs, translational factors and other ligands are being constructed and crystallized for structural analysis. Our ultimate goal is to assemble the resulting structures into a high-resolution 'movie' that will provide a description of translation as it occurs on the ribosome.