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CRYSTAL STRUCTURE OF THE RIBOSOME

CRYSTAL STRUCTURE OF THE RIBOSOME
核糖体的晶体结构
批准号：
6181422
负责人：
HARRY F NOLLER
金额：
$41.45万
依托单位：
UNIVERSITY OF CALIFORNIA SANTA CRUZ
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-04-01 至 2003-03-31
来源：
https://reporter.nih.gov/project-details/6181422
关键词：
X ray crystallography binding sites bioimaging /biomedical imaging crystallization genetic translation intermolecular interaction messenger RNA nucleic acid structure ribosomal RNA ribosomal proteins ribosomes structural biology transfer RNA translation factor

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中文摘要
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英文摘要
The long-term goal of this project is to understand the molecular mechanism of translation in terms of the three-dimensional structure of the ribosome and its interactions with its functional ligands. The purpose is to determine the structure of Thermus thermophilus 70S ribosomes, in complex with mRNA, tRNAs and translational factors in different states of the translational elongation cycle. The immediate goal is to study several functional co-crystal complexes at medium (ca. 9Angstrom units) resolution. The longer-term plan is to then focus on the most promising candidate for solution at much higher (ca. 3Angstrom units) resolution. It is expected that these results will not only provide a sound structural basis for understanding the mechanism of translation at the molecular level, but will also reveal a wealth of information about RNA structure and protein-RNA interactions in general.
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