MOTOR PROTEIN-INHIBITOR COMPLEX STRUCTURE DETERMINATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 通过小分子控制细胞骨架蛋白的作用是开发新疗法的主要途径。我们的兴趣是在原子分辨率水平上理解小分子调节剂对各种细胞骨架蛋白的调节机制。更具体地说，我们的研究涉及调节分子马达蛋白（如肌球蛋白）的小分子之间的相互作用。 因此，这项工作将为开发基于结构的设计提供基础，这将有助于我们的药物发现工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Control of the action of cytoskeletal proteins by small molecules presents a major avenue for developing novel therapies. Our interest is directed towards understanding mechanisms of regulation of various cytoskeletal proteins by small molecule modulators at the level of atomic resolution. More specifically, our studies involve looking at the interactions between small molecules that modulate molecular motor proteins such as myosins. Therefore, this work will provide the foundation for developing structure-based design that will allow aid in our drug discovery efforts.