MOTOR PROTEIN-INHIBITOR COMPLEX STRUCTURE DETERMINATION

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 通过小分子控制细胞骨架蛋白的作用为开发新疗法提供了主要途径。我们的兴趣在于了解小分子调节剂在原子分辨率水平上调节各种细胞骨架蛋白的机制。更具体地说，我们的研究涉及调节肌球蛋白等分子运动蛋白的小分子之间的相互作用。 因此，这项工作将为开发基于结构的设计奠定基础，从而有助于我们的药物发现工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Control of the action of cytoskeletal proteins by small molecules presents a major avenue for developing novel therapies. Our interest is directed towards understanding mechanisms of regulation of various cytoskeletal proteins by small molecule modulators at the level of atomic resolution. More specifically, our studies involve looking at the interactions between small molecules that modulate molecular motor proteins such as myosins. Therefore, this work will provide the foundation for developing structure-based design that will allow aid in our drug discovery efforts.