KINESIN-INHIBITOR COMPLEX STRUCTURE DETERMINATION

驱动蛋白抑制剂复合物结构测定

• 批准号: 7597885
• 负责人: KATJUSA BREJC
• 金额: $ 0.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597885
• 关键词: Binding; Binding Sites; Complex; Computer Retrieval of Information on Scientific Projects Database; Event; Funding; Goals; Grant; Institution; Kinesin; Microtubules; Molecular Conformation; Motor; Proteins; Research; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; base; inhibitor/antagonist; member

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Kinesins are members of a group of ATP-dependent motor proteins essential for a variety of microtubule based cellular transport events. The goal of our proposed research is to obtain structural information for a motor domain of a kinesin superfamily member when bound to a proprietary inhibitor. The information we acquire will be used to identify the binding site for the inhibitor and to gain a better understanding of the conformational states of this kinesin.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Kinesin是一组依赖于ATP的马达蛋白的成员，对于各种基于微管的细胞运输事件是必不可少的。我们提出的研究的目标是获得一个动蛋白超家族成员在与专有抑制剂结合时的运动域的结构信息。我们获得的信息将被用来确定该抑制剂的结合部位，并更好地了解该激动素的构象状态。