MOTOR PROTEIN-INHIBITOR COMPLEX STRUCTURE DETERMINATION

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 通过小分子控制细胞骨架蛋白的作用是开发新疗法的主要途径。我们的兴趣在于了解小分子调节剂在原子分辨率水平上对各种细胞骨架蛋白的调节机制。更具体地说，我们的研究涉及到调节肌球蛋白等分子马达蛋白的小分子之间的相互作用。因此，这项工作将为开发基于结构的设计提供基础，这将有助于我们的药物发现工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Control of the action of cytoskeletal proteins by small molecules presents a major avenue for developing novel therapies. Our interest is directed towards understanding mechanisms of regulation of various cytoskeletal proteins by small molecule modulators at the level of atomic resolution. More specifically, our studies involve looking at the interactions between small molecules that modulate molecular motor proteins such as myosins. Therefore, this work will provide the foundation for developing structure-based design that will allow aid in our drug discovery efforts.