IL-16 regulates mast cell chemotaxis and function through the tetraspanin CD9.

IL-16 通过四跨膜蛋白 CD9 调节肥大细胞趋化性和功能。

• 批准号: nhmrc : 300431
• 负责人: Prof Steven Krilis
• 金额: $ 31.06万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/il-16-regulates-tetraspanin-cd9/98468
• 关键词: IL; 16; regulates; mast; cell

Mast cells are found in humans and other mammals at strategic sites such as skin, lining of the airways and gut and provide a first line of defence against a variety of infections. These cells use a number of products that have profound effects in humans. In particular, these products are thought to be involved in defence against bacteria, viruses and are implicated in allergic conditions such as asthma. In normal circumstances mast cells are only found in the tissues and not in the peripheral blood. However, we have made the first observation that mast-like cells occur in the peripheral blood of patients with asthma and allergic conditions but not in normals. This finding changed the prevailing paradigm for mast cell biology. The products that can influence mast cell growth and function are vital to the understanding of how mast cells are involved in conditions such as human asthma. We have demonstrated that a protein (CD9) on mast cells in the tetraspanin family is a receptor for a product (IL-16) which is thought to be important in asthma and other inflammatory conditions. The understanding of how mast cells are regulated by IL-16 may lead to potential new therapies in conditions such as asthma and HIV-1 infection.

肥大细胞存在于人类和其他哺乳动物的关键部位，如皮肤、气道衬里和肠道，并为各种感染提供第一道防线。这些细胞使用许多对人类有深远影响的产品。特别是，这些产品被认为涉及防御细菌，病毒，并涉及过敏性疾病，如哮喘。在正常情况下，肥大细胞仅存在于组织中，而不在外周血中。然而，我们首次观察到肥大样细胞出现在哮喘和过敏性疾病患者的外周血中，而不是在正常人中。这一发现改变了肥大细胞生物学的主流模式。影响肥大细胞生长和功能的产物对于了解肥大细胞如何参与人类哮喘等疾病至关重要。我们已经证明，在四跨膜蛋白家族中的肥大细胞上的蛋白质（CD 9）是一种产物（IL-16）的受体，该产物被认为在哮喘和其他炎性疾病中是重要的。了解IL-16如何调节肥大细胞可能会导致哮喘和HIV-1感染等疾病的潜在新疗法。