Pathophysiological Mechanisms in the Antiphospholipid Syndrome: B2GPI Regulation of FXI-FXIa

抗磷脂综合征(APS)抗体结合的主要蛋白质称为β2-GPI。β2-GPI抗体与反复流产、宫内发育迟缓、血栓和中风有关。APS患者的治疗是用有显著副作用的药物治疗的。为了开发更有针对性和更有效的治疗APS的方法，需要更多地了解抗体是如何引起其影响的，这一点在本研究中得到了解决。

The major protein that the antibodies in the antiphospholipid syndrome (APS) bind is called Beta 2-GPI. Antibodies to Beta 2-GPI are associated with recurrent miscarriage, intrauterine growth retardation, clots and stroke. Treatment of patients with the APS are treated with medication that has significant side effects. The development of more targeted and effective therapies for the APS requires a greater understanding of how the antibodies cause their effects, which is addressed in this study.