NON-INVASIVE QUANTITATION OF CELLU & BIOCHEM CHANGES IN SPINOCEREBELLAR ATAXIAS

细胞的非侵入式定量

• 批准号: 7954939
• 负责人: Gulin Oz
• 金额: $ 1.28万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954939
• 关键词: Age; Ataxia; Biochemical; Cessation of life; Chicago; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Event; Friedreich Ataxia; Funding; Gliosis; Goals; Grant; Institution; LY6E gene; Magnetic Resonance Imaging; Multiple System Atrophy; NMR Spectroscopy; Nerve Degeneration; Neurology; Neurons; Oxidative Stress; Patients; Philanthropic Fund; Research; Research Personnel; Resources; Scanning; Source; Spectrum Analysis; Spinocerebellar Ataxias; United States National Institutes of Health; Universities; neurochemistry; oculomotor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. (in collaboration with Dr.s Khalaf Bushara, Neurology and Christopher Gomez, University of Chicago, Neurology, supported by R21 NS056172, philanthropic funds and Bob Allison Ataxia Research Center, PI Oz): In this project we study the neurochemical alterations that are associated with neurodegeneration in spinocerebellar ataxias (SCAs). The goal is to establish and validate markers of multiple cellular and biochemical events associated with neurodegeneration, such as neuronal death, gliosis and oxidative stress. We have so far scanned patients with SCA1, SCA2, SCA6, Friedreich's ataxia, cerebellar multiple system atrophy and ataxia with oculomotor apraxia type 2, as well as age-matched healthy controls. We have detected alterations in the neurochemical profile in ataxias by high field nuclear magnetic resonance spectroscopy (MRS) and found that these are specific for different ataxia subtypes.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 (与芝加哥大学神经病学和Christopher Gomez博士合作，神经病学，由R21 NS056172，慈善基金和Bob Allison共济失调研究中心，Pi Oz支持)：在这个项目中，我们研究了与脊髓小脑性共济失调(SCA)神经变性相关的神经化学改变。其目标是建立和验证与神经退行性变相关的多种细胞和生化事件的标记，如神经元死亡、胶质增生和氧化应激。到目前为止，我们已经扫描了SCA1、SCA2、SCA6、Friedreich‘s共济失调、小脑多系统萎缩和共济失调伴动眼运动性失用的2型患者，以及年龄匹配的健康对照组。我们通过高场核磁共振波谱(MRS)检测了共济失调患者神经化学特征的变化，并发现这些变化是不同共济失调亚型所特有的。