7th Ataxia Investigators Meeting, From Bench to Bedside: Entering a New Era of Ataxia Therapies

项目摘要/摘要 共济失调是一种致残性和经常致命的神经疾病，由多种遗传和 后天的病因。第七届共济失调症调查员会议，《AIM 2018：从板凳到床边：进入 新时代的共济失调疗法“将召集一个国际调查人员名册，以解决多样化的 共济失调的病因，更好地定义共济失调的致病基础，探索治疗途径，促进强有力的试验 在共济失调领域，并帮助在共济失调研究领域建立未来的领导者。这次会议将集中讨论 最新的科学进展和新出现的综合治疗方法，如下 目标：1)加深我们对小脑功能和功能障碍的理解；2)开发和评估 治疗策略；3)促进共济失调强大临床试验的发展；4)帮助建立未来 通过促进年轻研究人员的参与来领导共济失调研究；以及5)将受训人员带入 与共济失调患者及其家属接触。AIM 2018将是一个关键机制，以促进 在共济失调研究和治疗方法方面的合作和讨论，这在现在特别重要 该领域正在进入有意义的多中心临床试验阶段，在美国和 欧洲。2018年AIM会议，附属于最大共济失调年会并与之重叠 基金会在全国同一家酒店举行，将最大限度地发挥这次会议对科学家的影响 和病人一样。

PROJECT SUMMARY/ABSTRACT Ataxia, a disabling and frequently fatal neurological disorder, results from a wide variety of genetic and acquired etiologies. The 7th Ataxia Investigators' Meeting, “AIM 2018: From Bench to Bedside: Entering a New Era of Ataxia Therapies” will assemble an international roster of investigators to address the diverse causes of ataxia, better define the pathogenic basis of ataxia, explore routes to therapy, facilitate robust trials in ataxias, and help to establish future leaders in the ataxia research field. The conference will focus on the most recent scientific advances and emerging integrative approaches toward therapy, with the following objectives: 1) refine our understanding of cerebellar function and dysfunction; 2) develop and evaluate therapeutic strategies; 3) facilitate development of robust clinical trials in ataxias; 4) help to establish future leaders of ataxia research by facilitating the involvement of young investigators; and 5) bring trainees into contact with ataxia patients and their families. AIM 2018 will represent a critical mechanism to facilitate collaboration and discussion on ataxia research and therapeutic approaches, which is especially important now that the field is entering the phase of meaningful, multi-center clinical trials both in the United States and Europe. The AIM 2018 meeting, affiliated and overlapping with the annual meeting of the largest ataxia foundation in the country occurring at the same hotel, will maximize the impact of this meeting for scientists and patients alike.